Histological Liver Changes in Experimental Obstructive Cholestasis with Partial Outflow Restoration

Abstract

Objective: This work aimed to establish histological changes in the structure and activity of the liver caused by experimental obstructive cholestasis. Method: Several methodological approaches were used such as experimental, biochemical, and comparison were applied.Results: It was possible to describe the essence of such a disease as cholestasis and its impact on the liver. At the same time, it was proved that recanalization with incomplete recovery of bile outflow was possible due to the normalization of the total bilirubin (TB) level. Morphological changes in the liver were most pronounced during acute cholangitis. The study examined what processes occur in the body during the recovery of bile flow, including after the complete blockage of such organs as the liver and bile ducts. Consequently, signs that expressed the abnormality of the liver structure of animals were revealed.