Blood levels of histamine and norepinephrine in humans with sympathetic hyperactivity
Keywords:
Histamine, norepinephrine, peripheral sympathetic control, tetanus, Guillain-Barre syndrome, hypersympathetic activity, essential arterial hypertension.Abstract
The possible existence of a histaminergic pathway by which a reciprocal contralateral inhibitory modulation of the peripheral sympathetic nervous system is exerted motivated the present experimental clinical work. Blood levels of histamine (HA) and norepinephrine (NE) were measured in peripheral blood from patients with Tetanus or Guillain-Barre Syndrome (GBS), pathologies known to present sympathetic hyperactivity crisis in the course of its evolution; also in critically ill patients in general, hospitalized in Intensive Care Units (ICU); and in healthy voluntary donors from the Blood Banks.
La posible existencia de una vía histaminérgica, mediante la cual se ejerce una modulación inhibidora recíproca contralateral del sistema nervioso simpático periférico, motivó el presente trabajo clínico experimental. Se determinaron los niveles sanguíneos de histamina (HA) y norepinefrina (NE) en sangre periférica de pacientes con Tétanos o con Síndrome de Guillain-Barré (SGB), patologías que se sabe que presentan crisis de hiperactividad simpática en el curso de su evolución; igualmente en pacientes críticamente enfermos en general, hospitalizados en Unidades de Cuidados Intensivos (UCI); y en donantes voluntarios sanos de Bancos de Sangre.
