Analysis of the Relationship Between Soluble Cd40 Ligand and Homeostasis Model Assessment of Insulin Resistance in Obese Non-Diabetic Subjects

Authors

  • Nur Ismi Deparment of Biomedical Science, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Uleng Bahrun Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
  • Liong Boy Kurniawan Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
  • Andi Alfian Zainuddin Department of Public Health, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Siti Rafiah Department of Anatomi, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • Himawan Sanusi Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Keywords:

Obesity, HOMA-IR, sCD40L

Abstract

Obesity is a complex multifactorial disease characterized by the accumulation of body fat, leading to adverse effects on one’s well-being. Obesity has a strong association with insulin resistance. Insulin resistance can lead to a range of health issues, including type II diabetes mellitus, cardiovascular disease, and other metabolic syndrome diseases. A method that can be employed to evaluate insulin resistance is the measurement of HOMA-IR. sCD40L is the soluble form of the CD40L molecule released on the cell surface through proteolysis. There is evidence that the sCD40L level is a strong predictor of cardiovascular risk, and enhanced levels of CD40L were reported in patients with hypercholesterolemia, diabetes mellitus, and acute coronary syndromes.

Author Biographies

Nur Ismi, Deparment of Biomedical Science, Hasanuddin University, Makassar, South Sulawesi, Indonesia



Uleng Bahrun, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.



Andi Alfian Zainuddin, Department of Public Health, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia



Siti Rafiah, Department of Anatomi, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia



Himawan Sanusi, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia



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Published

2024-12-13

How to Cite

Ismi, N. ., Bahrun, U. ., Kurniawan, L. B. ., Zainuddin, A. A. ., Rafiah, S. ., & Sanusi, H. . (2024). Analysis of the Relationship Between Soluble Cd40 Ligand and Homeostasis Model Assessment of Insulin Resistance in Obese Non-Diabetic Subjects. Gaceta Médica De Caracas, 132(4). Retrieved from https://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/29955

Issue

Vol. 132 No. 4 (2024)

Section

ARTÍCULOS ORIGINALES

License

Copyright (c) 2024 Gaceta Médica de Caracas

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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