Can the Proinflammatory Cytokines IL-6 and TNF-α Act as Biomarkers of Autism Spectrum Disorder? A Literature Review

Authors

  • Nasruddin Syam Faculty of Public Health, Universitas Muslim Indonesia, Makassar, Indonesia
  • Anwar Mallongi Faculty of Public Health, Universitas Hasanuddin, Makassar, Indonesia. https://orcid.org/0000-0001-6438-1154
  • Anwar Daud Faculty of Public Health, Universitas Hasanuddin, Makassar, Indonesia. https://orcid.org/0000-0002-6236-6097
  • Muhammad Syafar Faculty of Public Health, Universitas Hasanuddin, Makassar, Indonesia. https://orcid.org/0000-0002-3667-7342
  • Alfina Baharuddin Faculty of Public Health, Universitas Muslim Indonesia, Makassar, Indonesia
  • Khidri Alwi Faculty of Public Health, Universitas Muslim Indonesia, Makassar, Indonesia
  • Wardiah Hamzah Faculty of Public Health, Universitas Muslim Indonesia, Makassar, Indonesia

Keywords:

IL-6, TNF-α, autism spectrum disorder

Abstract

Background: WHO reports that out of 160 children, one of them has autism spectrum disorder (ASD). Experts estimate that the cause of autism could be heavy metals. This review aims to assess the progress of research on the potential use of IL-6 and TNF-α cytokines as ASD biomarkers. Methods: This review uses sources from the PubMed and ScienceDirect databases. The keywords used were IL-6 AND TNF-α AND (Autism OR Autism Spectrum Disorder OR ASD). At the research identification stage, 63 studies were obtained, and after the screening, 12 studies were found that met the requirements for a review.

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Published

2024-09-03

How to Cite

Syam, N. ., Mallongi, A. ., Daud, A. ., Syafar, M. ., Baharuddin, A. ., Alwi, K. ., & Hamzah, W. . (2024). Can the Proinflammatory Cytokines IL-6 and TNF-α Act as Biomarkers of Autism Spectrum Disorder? A Literature Review. Gaceta Médica De Caracas, 132(3), 754–760. Retrieved from https://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/29269

Issue

Section

ARTÍCULOS DE REVISIÓN

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