Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go

Authors

  • Yudith Annisa Ayu Rezkitha Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia https://orcid.org/0000-0001-7600-9114
  • Camilia Metadea Aji Savitri Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia
  • Maria Inge Lusida Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia
  • Siprianus Ugroseno Yudho Bintoro 4 Department of Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
  • Lita Diah Rahmawati Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Reny I’tishom 6 Department of Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia
  • Muhammad Miftahussurur 7 Division of Gastroenterology-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia https://orcid.org/0000-0003-1415-6033

Keywords:

Colorectal cancer, epigenetics, DNA methylation, histone modification, RNA therapeutics, cancer

Abstract

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.

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Published

2022-07-11

How to Cite

Ayu Rezkitha, Y. A. ., Aji Savitri, C. M. ., Lusida, M. I. ., Yudho Bintoro, S. . U. ., Rahmawati, L. D. ., I’tishom, R. ., & Miftahussurur, M. . (2022). Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go. Gaceta Médica De Caracas, 130(2). Retrieved from https://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/24057

Issue

Vol. 130 No. 2 (2022)

Section

ARTÍCULOS DE REVISIÓN

License

Copyright (c) 2022 Gaceta Médica de Caracas

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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