Gaceta Médica Medicina Academia Cardiología Neurología Ginecología Cirugía

Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go

Autores/as

Yudith Annisa Ayu Rezkitha Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia https://orcid.org/0000-0001-7600-9114
Camilia Metadea Aji Savitri Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia
Maria Inge Lusida Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia
Siprianus Ugroseno Yudho Bintoro 4 Department of Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Lita Diah Rahmawati Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
Reny I’tishom 6 Department of Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia
Muhammad Miftahussurur 7 Division of Gastroenterology-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia https://orcid.org/0000-0003-1415-6033

Palabras clave:

Colorectal cancer, epigenetics, DNA methylation, histone modification, RNA therapeutics, cancer

Resumen

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.

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Publicado

2022-07-11

Cómo citar

Ayu Rezkitha, Y. A. ., Aji Savitri, C. M. ., Lusida, M. I. ., Yudho Bintoro, S. . U. ., Rahmawati, L. D. ., I’tishom, R. ., & Miftahussurur, M. . (2022). Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go. Gaceta Médica De Caracas, 130(2). Recuperado a partir de https://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/24057

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Número

Vol. 130 Núm. 2 (2022)

Sección

ARTÍCULOS DE REVISIÓN

Licencia

Derechos de autor 2022 Gaceta Médica de Caracas

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

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