Effects of physiotherapy-based interventions on functional neural recovery following peripheral nerve injury in rodent models - a systematic review

Efectos de las intervenciones fisioterapéuticas en la recuperación neuronal funcional tras una lesión nerviosa periférica en modelos de roedores: una revisión sistemática

Abstract

Peripheral nerve injuries often lead to significant motor and sensory impairments and seldom achieve complete functional recovery following surgical reconstruction; thus, it is crucial to integrate rehabilitation methods that promote peripheral nerve regeneration. A systematic review analyzed 22 preclinical studies examining the impact of physiotherapy interventions on neural recovery following peripheral nerve injury; the research covered a wide variety of physiotherapy interventions and outcomes. The search adhered to PRISMA guidelines. Research articles on various physiotherapy methods, such as exercise, neuromodulation techniques, and electrotherapy, for the rehabilitation of neural functions were retrieved from electronic databases. Overall trends indicated consistent enhancements in functional recovery and nerve regeneration with exercise-based and neuromodulatory approaches compared to electrotherapeutic methods.