The relationship between poly ADP-ribose polymerase-1 gene expression and protein kinase β expression with neoadjuvant chemotherapy response in triple negative breast cancer subtype

Relación entre la expresión del gen de la poli ADP-ribosa polimerasa-1 y la expresión de la proteína cinasa β en la respuesta a la quimioterapia neoadyuvante en el subtipo de cáncer de mama triple negativo

Abstract

Introduction: Breast cancer is the most common and deadliest cancer among women worldwide. One of its subtypes with a particularly poor prognosis is triple‐negative breast cancer (TNBC). Patients with TNBC often receive various therapeutic approaches, including neoadjuvant chemotherapy. However, the wide genetic heterogeneity of TNBC results in highly variable responses to chemotherapy. Poly(ADP-ribose) polymerase-1 (PARP1) expression, a defense mechanism against chemotherapy, and Protein Kinase β (AKT) activation, which increases tumor aggressiveness, are thought to influence chemotherapy responses in these patients.