Effect of ACTH4-10pro8-gly9-pro10 on malondialdehyde and F2-isoprostane 15(S)-8-iso-PGF2a expression in rat spinal cord injury

Rifqi Aulia  Destiansyah; Eko Agus  Subagio; Muhammad Arifin  Parenrengi; Budi  Utomo; Muhammad  Faris; Abdul Hafid  Bajamal; Diaz Syafrie  Abdillah

Authors

Rifqi Aulia Destiansyah Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia http://orcid.org/0000-0001-8933-8785
Eko Agus Subagio Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia http://orcid.org/0000-0002-6790-3779
Muhammad Arifin Parenrengi Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia http://orcid.org/0000-0002-1327-8955
Budi Utomo Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia http://orcid.org/0000-0001-6060-9190
Muhammad Faris Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia http://orcid.org/0000-0002-8377-6773
Abdul Hafid Bajamal Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia http://orcid.org/0000-0003-3824-6973
Diaz Syafrie Abdillah Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya, Surabaya, Indonesia http://orcid.org/0000-0001-8387-1052

Keywords:

ACTH4-10Pro8 -Gly9 -Pro10, spinal cord injury, reactive oxygen species, malondialdehyde, F2-isoprostane

Abstract

Background: Spinal cord injury (SCI) is damage to the spinal cord caused mainly by trauma resulting in major motor, sensory, and autonomic dysfunctions. This experimental study aims to assess the effect of ACTH4-10Pro8-Gly9-Pro10 administration in rats with mild and severe compression injuries on the levels of malondialdehyde and F2-isoprostane 15(S)-8-iso-PGF2α levels. Methods: Mild and severe spinal cord compression was performed on 27 subjects. They were divided into three groups of samples with control included, 3 and 6 h after the injury.

Effect of ACTH4-10pro8-gly9-pro10 on malondialdehyde and F2-isoprostane 15(S)-8-iso-PGF2a expression in rat spinal cord injury

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