The role of stabilization of mast cell membranes by sodium cromoglicate in smooth muscle contraction of trachea and bronchi of the rat in the conditions of the physiological norm

Resumo

The article discusses the role of stabilization of mast cell membranes with sodium cromoglycate in the contractile activity of smooth muscles of the trachea and bronchi. The studies were carried out on isolated preparations using electrical stimulation of postganglionic nerves (frequency - 30 stim/s, duration - 0.5 ms, amplitude - 20 V, duration of stimulation - 10 s). As a result of the study, it was found that the stabilization of mast cell membranes with sodium cromoglycate promotes an increase in the contractile activity of smooth muscle under physiological conditions. An increase in muscle contraction in response to sodium cromoglycate developed even after the atropine blockade of cholinergic receptors. When C-fibers were inactivated, the muscle contractile responses obtained after the administration of sodium cromoglycate decreased. Probably, the bronchoconstrictor effect of sodium cromoglycate is caused by the elimination of the dilating function of mast cells under normal physiological conditions.