Influence of recombinant erythropoietin on mesenchymal stem cells proliferation and differentiation during cultivation on allogenic bone matrix

Authors

  • Sergey V. Nadezhdin
  • Ekaterina V. Zubareva
  • Anatoliy V. Ovsyankin
  • Svetlana A. Guzyukina
  • Elena A. Atamanyuk
  • Ekaterina S. Gnezdyukova
  • Kseniya R. Zhukovskaya

Keywords:

mesenchymal stem cells (MSCs), recombinant erythropoietin, allogenic bone matrix, proliferation, differentiation.

Abstract

Effectiveness of mesenchymal stem cells(MSCs) proliferation and differentiation wasstudied after addition of medicinal productcontaining human recombinant erythropoietin (rhEPO)into enriched culture medium with components for osteoandangiogenesis. Cultivation of mesenchymal stem cellsunder static conditions using “cocktail” of growth factorsand rhEPO allowed to populate allogenic discs-scaffoldswith connective tissue formations with the participationof osteoblasts and elongated multicellular structures,which formed after endothelium-like cells fusion. In thepresence of rhEPO MSCs differentiates more effectively inosteogenic direction than in angiogenic.

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Issue

Vol. 14 No. 4 (2019): Latinoamericana de Hipertensión

Section

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