Effects of Nonsteroidal Anti-Infl ammatory Drug on Prevalence of Helicobacter Like Organisms in Gastric Mucosa of Thoroughbreds Horses

Abstract

The aim of this study was describe effects of Nonsteroidal Anti-inflammatory drug on prevalence of Helicobacter Like Organisms in gastric mucosa of Thoroughbreds horses. Were studied 54 Thoroughbred horses in the national race Track “La Rinconada” Caracas-Venezuela. All equine were treated by seven days with phenylbutazone at an intravenous dose of 4.4 mg/kg. All horses presented Equine gastric ulcer syndrome acute superficial gastritis (25/54), chronic gastritis with erosion focal (16/54), chronic gastritis with erosion focal and ulcers (14/54) in the gastric in both regions mucosa squamous region and glandular regions (fundus). Helicobacter Like Organisms infection in the stomach was confirmed by Warthin- Starry (38/54). Gastric mucosa revealed numerous spiralshaped bacteria morphologically resembling Helicobacter Like Organisms in squamous regions, margo plicatus (20/38) and numerous spiral-shaped bacteria in fundic glands (18/54). Inconclusion, we detected high presence of Helicobacter Like Organisms in the gastric mucosa of Thoroughbred horse’s treatment with phenylbutazone.