Saber UCV
Repositorio Institucional
Repositorio Institucional
Please use this identifier to cite or link to this item:
https://saber.ucv.ve/handle/10872/1697
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| Title: | Antitrypanosomal Activity of Quaternary Naphthalimide Derivatives |
| Authors: | Muth, Mathias Hoerr, Verena Glaser, Melanie Ponte-Sucre, Alicia Moll, Heidrun Stich, August Holzgrabe, Ulrike |
| Keywords: | Sleeping sickness Trypanosoma brucei quaternary and tertiary naphthalimides |
| Issue Date: | 23-Aug-2012 |
| Series/Report no.: | Bioorganic Medicinal Chemistry Letters;17: 1590-1593, 2007 |
| Abstract: | Sleeping sickness caused by Trypanosoma brucei gambiense and rhodesiense is fatal if left untreated. Due to the toxicity of drugs currently used and the emerging resistance against these drugs new lead compounds are urgently needed. Within the frame of a broad screening program for drugs with antitrypanosomal activity, some highly potent tertiary and quaternary mono- and bisnaphthalimides being active in the lower micromolar and nanomolar range of concentration have been identified. These compounds are easily available via a two- or three-step microwave-driven synthesis with high yield. |
| URI: | http://hdl.handle.net/10872/1697 |
| ISSN: | 0960-894X |
| Appears in Collections: | Artículos Publicados |
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