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https://saber.ucv.ve/jspui/handle/10872/1697Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Muth, Mathias | - |
| dc.contributor.author | Hoerr, Verena | - |
| dc.contributor.author | Glaser, Melanie | - |
| dc.contributor.author | Ponte-Sucre, Alicia | - |
| dc.contributor.author | Moll, Heidrun | - |
| dc.contributor.author | Stich, August | - |
| dc.contributor.author | Holzgrabe, Ulrike | - |
| dc.date.accessioned | 2012-08-23T17:08:47Z | - |
| dc.date.available | 2012-08-23T17:08:47Z | - |
| dc.date.issued | 2012-08-23 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | http://hdl.handle.net/10872/1697 | - |
| dc.description.abstract | Sleeping sickness caused by Trypanosoma brucei gambiense and rhodesiense is fatal if left untreated. Due to the toxicity of drugs currently used and the emerging resistance against these drugs new lead compounds are urgently needed. Within the frame of a broad screening program for drugs with antitrypanosomal activity, some highly potent tertiary and quaternary mono- and bisnaphthalimides being active in the lower micromolar and nanomolar range of concentration have been identified. These compounds are easily available via a two- or three-step microwave-driven synthesis with high yield. | es_VE |
| dc.description.sponsorship | Deutsche Forschungsgemeinschaft, National Institute of Health | es_VE |
| dc.language.iso | en_US | es_VE |
| dc.relation.ispartofseries | Bioorganic Medicinal Chemistry Letters;17: 1590-1593, 2007 | - |
| dc.subject | Sleeping sickness | es_VE |
| dc.subject | Trypanosoma brucei | es_VE |
| dc.subject | quaternary and tertiary naphthalimides | es_VE |
| dc.title | Antitrypanosomal Activity of Quaternary Naphthalimide Derivatives | es_VE |
| dc.type | Article | es_VE |
| Aparece en las colecciones: | Artículos Publicados | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Muth et al., BMC 2007.pdf | 136.32 kB | Adobe PDF | Visualizar/Abrir |
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