Saber UCV
Repositorio Institucional
Repositorio Institucional
Please use this identifier to cite or link to this item:
https://saber.ucv.ve/handle/10872/15170
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| Title: | Total and Biologically Active Serum-Soluble CD154 in Patients with Chronic Idiopathic Urticaria |
| Authors: | Garmendia, Jenny V. Zabaleta, Mercedes Blanca, Isaac Bianco Colmenares, Nicolás E. De Sanctis, Juan B. |
| Keywords: | Biologically Active Serum-Soluble CD154 Chronic Idiopathic Urticaria CIU autoimmunity autoimmune diseases |
| Issue Date: | 2004 |
| Publisher: | Allergy and asthma proceedings |
| Series/Report no.: | Vol. 25;No. 2 pp 121-125 |
| Abstract: | The pathogenesis of chronic idiopathic urticaria (CIU) is not understood completely; however, autoimmunity has been implicated. Because membrane and soluble forms of CD154 have been reported to be increased, in several autoimmune diseases, we have quantified the soluble CD154 (sCD154) molecule by a sandwich enzyme-linked immunosorbent assay in serum samples of 32 patients with CIU (aged 32 +/- 12 years) and compared them with 32 age- and sex-matched nonallergic controls. A marked increase was observed in patients with CIU as compared with controls (4.8 +/- 2.6 ng/mL versus 2.9 +/- 0.9 ng/mL; p < 0.0005). No significant differences were found between groups of patients with positive or negative autologous serum skin test. A biological assay to determine sCD154 showed that patients with positive autologous serum skin test have the highest levels (4.9 +/- 1.2 ng/mL) of biologically active sCD154 as compared with their negative counterparts (2.2 +/- 1.3 ng/mL; p < .001) and controls (0.6 +/- 0.3 ng/mL; p < 0.001). Active sCD154 can be derived from mast cell activation or other leukocytes. It is concluded that active sCD154 may be involved in the immune activation observed in patients with CIU. |
| URI: | http://hdl.handle.net/10872/15170 |
| ISSN: | 1539-6304 (Electronic) 1088-5412 (Linking) 1088-5412 (Print) |
| Appears in Collections: | Artículos Publicados |
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