Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/14421
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| Title: | Helper Activity by Human Large Granular Lymphocytes in in Vitro Immunoglobulin Synthesis |
| Authors: | Rodriguez, Martin A. Blanca, Isaac Baroja, Miren L. Arama, Simy Leon-Ponte, Matilde Abadí, Isaac Bianco Colmenares, Nicolás E. |
| Keywords: | Large granular lymphocytes B lymphocytes immunoglobulin synthesis helper Iymphocyte function mitogen-activated LGL |
| Issue Date: | 1987 |
| Publisher: | Journal of Clinical lmmunology |
| Series/Report no.: | Vol. 7;No. 5 pp 356-364 |
| Abstract: | In the present study we have examined the effect of human large granular Iymphocytes (LGL) from health y donors on Ig synthesis by autologous B Iymphocytes. The results showed that this cell population has a consistent helper activity in pokeweed mitogen-activated cultures even when added at very low numbers. LGL can mediate their effect by secreting soluble helper factors capable of modulating B-cell responses as evidenced by the enhancement of IgG and IgM production by supernatants obtained from LGL cultures. Preincubation with interferon gamma further potentiated the helper activity by LGL. |
| URI: | http://hdl.handle.net/10872/14421 |
| ISSN: | 1573-2592 |
| Appears in Collections: | Artículos Publicados |
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