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Please use this identifier to cite or link to this item: https://saber.ucv.ve/jspui/handle/10872/14421
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dc.contributor.authorRodriguez, Martin A.-
dc.contributor.authorBlanca, Isaac-
dc.contributor.authorBaroja, Miren L.-
dc.contributor.authorArama, Simy-
dc.contributor.authorLeon-Ponte, Matilde-
dc.contributor.authorAbadí, Isaac-
dc.contributor.authorBianco Colmenares, Nicolás E.-
dc.date.accessioned2017-02-10T17:00:11Z-
dc.date.available2017-02-10T17:00:11Z-
dc.date.issued1987-
dc.identifier.issn1573-2592-
dc.identifier.urihttp://hdl.handle.net/10872/14421-
dc.description.abstractIn the present study we have examined the effect of human large granular Iymphocytes (LGL) from health y donors on Ig synthesis by autologous B Iymphocytes. The results showed that this cell population has a consistent helper activity in pokeweed mitogen-activated cultures even when added at very low numbers. LGL can mediate their effect by secreting soluble helper factors capable of modulating B-cell responses as evidenced by the enhancement of IgG and IgM production by supernatants obtained from LGL cultures. Preincubation with interferon gamma further potentiated the helper activity by LGL.en_US
dc.language.isoenen_US
dc.publisherJournal of Clinical lmmunologyen_US
dc.relation.ispartofseriesVol. 7;No. 5 pp 356-364-
dc.subjectLarge granular lymphocytesen_US
dc.subjectB lymphocytesen_US
dc.subjectimmunoglobulin synthesisen_US
dc.subjecthelper Iymphocyte functionen_US
dc.subjectmitogen-activateden_US
dc.subjectLGLen_US
dc.titleHelper Activity by Human Large Granular Lymphocytes in in Vitro Immunoglobulin Synthesisen_US
dc.typeArticleen_US
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