Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/14057
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| Title: | (6R,9S)-6′′-(4′′-Hydroxybenzoyl)-Roseoside, a New Megastigmane Derivative from Ouratea polyanthaand its Effect on Hepatic Glucose-6-phosphatase |
| Authors: | Bermúdez, Jairo Rodríguez, María del C. Hasegawa, Masahisa González-Mujica, Freddy Duque, Sandra Ito, Yoichiro |
| Keywords: | Agathisflavone Countercurrent chromatography Glucose-6-phosphatase Megastigmanes Ouratea polyantha Terpenes (6R,9S)-6′-(4′′- Hydroxybenzoyl)-roseoside |
| Issue Date: | 2012 |
| Publisher: | Natural Product Communications |
| Citation: | Volumen 7, Número 8, páginas 1-4 |
| Abstract: | A new megastigmane derivative, (6R,9S)-6′-(4′′-hydroxybenzoyl)-roseoside(1)and two known compounds, the biflavoneagathisflavone(2) and 4- hydroxybenzoic acid (3) were isolated and purified from leaves and stems of Ouratea polyantha Engl. Agathisflavone was isolated in a single high-speed counter-current chromatography run, while the megastigmane was purified in two steps, by using a combination of high-speed countercurrent chromatography and analytical column chromatography. All structures were elucidated on the basis of spectral evidence and comparison with literature data. Compound 1 was characterized by []D 20, UV-Vis, IR, MS, 1H NMR, 13C NMR, HMQC, HMBC, COSY and NOESY. Compounds 1 and 2 showed an inhibitory effect of 63.6 and 13.7% on the G-6-Pase intact microsomes, respectively. |
| URI: | http://hdl.handle.net/10872/14057 |
| ISSN: | 1555-9475 |
| Appears in Collections: | Artículos Publicados |
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