Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go | Gaceta Médica de Caracas

Gaceta Médica Medicina Academia Cardiología Neurología Ginecología Cirugía

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Publicado: Jul 11, 2022

Palabras clave:

Colorectal cancer, epigenetics, DNA methylation, histone modification, RNA therapeutics, cancer

Yudith Annisa Ayu Rezkitha

Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia

https://orcid.org/0000-0001-7600-9114

Camilia Metadea Aji Savitri

Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia

Maria Inge Lusida

Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia

Siprianus Ugroseno Yudho Bintoro

4 Department of Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

Lita Diah Rahmawati

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia

Reny I’tishom

6 Department of Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia

Muhammad Miftahussurur

7 Division of Gastroenterology-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia

https://orcid.org/0000-0003-1415-6033

Resumen

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.

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Cómo citar

Ayu Rezkitha, Y. A. ., Aji Savitri, C. M. ., Lusida, M. I. ., Yudho Bintoro, S. . U. ., Rahmawati, L. D. ., I’tishom, R. ., & Miftahussurur, M. . (2022). Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go. Gaceta Médica De Caracas, 130(2). Recuperado a partir de http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/24057

Número

Vol. 130 Núm. 2 (2022)

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ARTÍCULOS DE REVISIÓN

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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

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