Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go

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Yudith Annisa Ayu Rezkitha
Camilia Metadea Aji Savitri
Maria Inge Lusida
Siprianus Ugroseno Yudho Bintoro
Lita Diah Rahmawati
Reny I’tishom
Muhammad Miftahussurur

Resumen

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. Various genetic and epigenetic changes in colonic epithelial cells, including DNA methylation, histone modifications, and noncoding RNAs, were involved in the initiation and progression of CRC. Moreover, epigenetic changes played an important role in CRC drug resistance. The dynamic and reversibility of epigenetic changes provide new possible therapeutic targets for colorectal cancer.

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Ayu Rezkitha, Y. A. ., Aji Savitri, C. M. ., Lusida, M. I. ., Yudho Bintoro, S. . U. ., Rahmawati, L. D. ., I’tishom, R. ., & Miftahussurur, M. . (2022). Epigenetic Approach on Colorectal Cancer Systemic Therapy: Promising yet a Long Way to Go. Gaceta Médica De Caracas, 130(2). Recuperado a partir de http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/24057
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