Características y significado de los factores de riesgo en el desarrollo de síndromes hematológicos en niños
Palabras clave:
anemia ferropénica, leucopenia, ferropenia, niños, factores de riesgoResumen
Para identificar las causas del desarrollo de enfermedades del sistema sanguíneo y del aparato hematopoyético en niños en las primeras etapas de su formación, se estudiaron los factores de riesgo para el desarrollo de anomalías hematológicas en niños de 1378 niños que viven en Rusia. Para esto, se utilizaron los resultados de la anamnesis y los métodos de investigación de diagnóstico de laboratorio. Se tuvieron en cuenta los datos de sangre periférica, metabolismo del hierro, análisis bioquímico y hematopoyesis de la médula ósea. Los resultados del estudio permitieron identificar factores de riesgo para el desarrollo de anomalías hematológicas en los niños. Se determinó que las anomalías hematológicas persistentes en los niños pueden formarse en el contexto de inferioridad congénita o daño intrauterino al sistema hematopoyético, causado por la influencia de factores desfavorables en las etapas ante y posnatal del desarrollo, trastornos alimentarios, inmadurez y falla del sistema inmunohematológico. sistema. Las desviaciones hematológicas que surgen en respuesta a la acción de factores endógenos y exógenos se pueden considerar como transformaciones adaptativas de los parámetros sanguíneos periféricos, lo que refleja la reacción general del sistema hematopoyético. Tener en cuenta los factores de riesgo permite agrupar a los niños en grupos de riesgo para la aparición de síndromes hematológicos en las primeras etapas del desarrollo, para diagnosticarlos y tratarlos a tiempo.
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Alakaeva I.B., Nepokulchitskaya N.V., Samsygina G.A., Vysotskaya T.A. Features of hematopoiesis in the prenatal period and the effect of congenital infections on it // Pediatrics. - 2009. - No. 4. - S. 124-128.
Afanasiev B.V., Zubarovskaya L.S. Myelodysplastic syndrome in children // Russian Journal of Pediatric Hematology and Oncology. - 2018. - No. 3. - S. 23-35.
Balasheva I.I., Desyatova L.F. The role of the constitutional factor in clinical polymorphism in children with acute lymphoblastic leukemia // Siberian Journal of Oncology. - 2012; (6): 64-67.
Vedrintsev V.V., Moshurov I.P. Oncological situation in the Voronezh region. / In the book: Collection of scientific articles; edited by I.E. Esaulenko et al. Voronezh: Scientific book, 2014: 10-17.
Zakharova IN, Tarasova IS, Chernov VM, Machneva EB and others. Risk factors for the development of iron deficiency states in adolescents in the city of Moscow // Pediatric Pharmacology. - 2015; 12 (5): 609-613.
Zaplatnikov A.L., Kuznetsova O.A., Vorob'eva A.S. Algorithm for verifying the nature of anemia based on the correct interpretation of indicators of clinical blood analysis // RMZh. - 2017; 12: 908-912.
Ilchenko S.I., Korenyuk E.S., Fialkovskaya A.A. Neutropenia in children: clinical masks and medical tactics / "Child health". - 2018; 13 (4): 387-393.
Kaznacheev K.S. Complex issues of early diagnosis of acute leukemia in children // Vestnik NSU. Series: Biology and Clinical Medicine. - 2011; 9 (2): 211-214.
Latypova L.F., Amirova E.F., Ryanova R.N., Fazlyeva L.G. Comparative assessment of the informativeness of indicators of risk factors for iron deficiency anemia as etiological factors in the formation of abnormalities in the state of health of children // Scientific and practical journal "Diary of the Kazan Medical School", issue No. 1 (XV), April, 2017.- P.44-48.
Odinets Yu.V., Panfilova E.A., Panfilov K.V. Debut "masks" of acute leukemia in children // Health of the child. - 2008; (3): 37-41.
Orynbasarova K.K., Dzhatsybaeva I.S., Ismailova D.B. Comparative characteristics of hematological changes in children with cytomegalovirus infection // Bulletin of KazNMU. -2018.-. No. 1.-C. 54-56
Rumyantsev A.G., Zakharova I.N., Tarasova I.S., Zaplatnikov A.L., Korovina N.A. et al. Prevalence of iron deficiency states and factors affecting it // Medical Council. - 2015. -№6.- S. 62-67.
Spichak I.I., Gerasimova A.V., Teplykh E.V. Neutropenias, including febrile ones, as a frequent and natural event in a specialized pediatric oncological hospital // Pediatric Bulletin of the Southern Urals. - 2014. - No. 3. - P.1-2.
Tayupova I.M. On the issue of rational nutrition, correction of micronutrient status, prevention and treatment of iron deficiency in pregnant women // Questions of nutrition. - 2015.- Volume 84, No. 2.- P.25-33
Tyutyunnik V.L., Kan N.E., Mikhailova O.I., Dubrovina N.V. Evaluation of the effectiveness of therapy for iron deficiency anemia in pregnant women with Maltofer. // Effective pharmacotherapy. - 2017; 26: 4-11.
Cherepanova V.V., Mikhailova Z.D., Mikhailova Yu.V., Sinkova V.V. Neutropenia: Old Problem - New Reading. Advice from a hematologist to a cardiologist // Cardiology: opinion news, training. - 2019. - T. 7, No. 1. - P. 47-50.
Chesnokova N.P., Nevvazhai T.A., Ponukalina E.V. and others. Lecture 2. Acquired leukopenias: classification, etiological factors, importance in the development of pathology // International Journal of Experimental Education. - 2015. - No. 7. - S. 180-183.
Shashel V.A., Bishenova A.A., Potyagailo E.G., Shchegolevataya N.N. Epidemiological risk factors for iron deficiency in children and adolescents of the Krasnodar Territory // Kuban Scientific Medical Bulletin. - 2017; 24 (4): 162-168.
Erman M.V. Iron deficiency anemia in children // Questions of practical pediatrics. - 2014. - T. 9. - No. 1. - P. 1-4.
Yudina NB, Brezhneva NV Isolated neutropenia in children: from pediatrician to hematologist // Russian Journal of Pediatric Hematology and Oncology. - 2015; 2 (1): 75-80.
Aigner E., Feldman A., Datz Ch. Obesity as an Emerging Risk Factor for Iron Deficiency // Nutrients. 2014.- Sep; 6 (9): 3587-3600
Babushok D.V., Bessler M. Genetic predisposition syndromes: when should they be considered in the work-up of MDS? Best Pract. Res Clin. Haematol. 2015; 28 (1): 55-68.
Bannon A., Di Nardo C. Hereditary predis-positopn to myelodysplastic syndrome. Int J. Mol. Sci. 2016; 17 (6).
Cheng S., Pole J.D., Sung L. Early deaths in pediatric acute leukemia: a population-based study // Leuk. Lymphoma. 2014; 55 (7): 1518-1522.
Colin M., Dickinson R., Bigley V. Hematopoietic and immune defects associated with the GATE 2 mutation // Br J. Haematol. 2015; 169: 173.
Farrugia P., Dufour S. Diagnosis and treatment of primary autoimmune neutropenia in children: conclusions for clinicians // The Adv Hematol. 2015; 6: 15-24.
Glenthaj A., 0rskov A.D., Hansen J.W. et al. Immune mechanisms in myelodysplastic syndrome. // Int. J. Mol. Sci. 2016 Jun 15; 17 (6).
Hasle H. Myelodysplastic and myeloproliferative disorders of childhood. Hematology Am. Soc. Hematol. Educ. Program. 2016; 2016 (1): 598-604.
Husain E. H., Mullah-Ali A., Al-Sharidah S. et al. Infectious etiologies of transient neutropenia in previously healthy children // Pediatr Infect Dis J 2012; 31: 575-7.
Inoue S., Wolfe L.C., Windle M.L., Crouch G.D., Jones G. Pediatric Autoimmune and Chronic Benign Neutropenia Differential Diagnoses. Available from: https://emedicine.medscape.com/article/954781-differential. Accessed: November 28, 2017.
Lindquist H., Carlson G., Moll J. and others. Neutropenia in childhood: 5 years of experience in the tertiary center // Eur. J. Pediatr. 2015, June; 174 (6): 801-7.
Mary Territo, M. D., David Geffen. Overview of Leukopenias. School of Medicine at UCLA. Last full review / revision. - July, 2018, by Mary Territo, M.D.
Mourot-Cottet R., Maloisel F., Severac F. et al. Idiosyncratic drug-induced severe neutropenia and agranulocytosis in elderly patients (> 75 years): a monocentric cohort study of 61 cases // Drugs Real World Outcomes. 2016. Vol. 3, No. 4. - P. 393-399.
Newburger P.E. Autoimmune and other acquired neutropenias // Hematology Am. Soc. Hematol. Educ. Program. 2016. Vol. 1. - P. 38-42.
Pande S., Ranjan R., Kratasyuk V.A. Is Body Mass Index a potential biomarker for anemia in obese adolescents? // Journal of Nutrition and Intermediary Metabolism.-2019. Vol. 15.- P.1-2
Roques G., Munzer M., Barthez M. A., et al. Neurological data and genetic changes in patients with Kostmann syndrome and hax1 mutations // Pediatrics. Blood cancer. 2014; 61: 1041-8.
Skokowa J., Steinemann D., Makaryan V. et al. RUNX1 mutations are the most frequent leukemia associated mutations in congenital neutropenia patients // ASH Annual Meeting Abstracts. 2012; 120: 7.18.
Waldvogel-Abramowski S. Physiology of iron metabolism / S. Waldvogel-Abramowski, G. Waeber, C. Gassner [et al.] // Transfus. Med. Hemother. - 2014. - Vol. 41. - No. 3. -P. 213-221.
WHO Global Database on Anaemia Geneva, World Health Organization, 2008.
WHO Global Database on Iron Deficiency and Anaemia, Micronutrient Deficiency Information System. Geneva, World Health Organization, 2005.
The article was published with the support of the scientific publishing house "Vzglyad Uchenogo" https://scientist-view.ru
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