Efecto protector del zinc y su relación con algunos parámetros hematológicos, bioquímicos e histológicos en ratas macho adultas
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Zinc, colesterol, parámetros hematológicos, hígadoResumen
El oligoelemento zinc es esencial para la construcción y función de las proteínas celulares. El estudio actual tuvo como objetivo estimar la causa mejorada de zinc en los cambios resultantes de altas concentraciones de colesterol. En este experimento, treinta ratas macho de 3 a 4 meses de edad se dividieron aleatoriamente en tres grupos de diez ratas cada uno. Grupo control: los animales no recibieron ningún tratamiento, grupo colesterol: los animales recibieron colesterol en una concentración de 400 mg/kg mezclado con la dieta durante 4 semanas, mientras que en el grupo zinc: las ratas recibieron colesterol en una concentración de 400 mg/kg durante 4 semanas, luego se le administró zinc a 20 mg/kg durante otras 4 semanas. El periodo de estudio fue de 56 días, luego de su realización se estudiaron parámetros hematológicos y bioquímicos, además del examen histológico del hígado. Los resultados mostraron que el tratamiento del colesterol por sí solo condujo a cambios negativos significativos en los índices hematológicos, bioquímicos e histológicos. Mientras que la administración de zinc a ratas experimentales resultó en claros efectos positivos en esos parámetros. Llegamos a la conclusión de que las ratas dañadas por el colesterol mejoraron después de recibir zinc.
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Derechos de autor 2023 AVFT – Archivos Venezolanos de Farmacología y Terapéutica
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