Safety and immunogenicity of vaccines against SARS-CoV-2
Keywords:
SARS-CoV-2; Vaccine; ChAdOx1-S; Sinovac´s Coronavac; Gam-COVID-Vac.Abstract
The mortality rate estimated by the WHO worldwide for COVID-19 has been 5.7%, much higher than other communicable infectious diseases, so it is essential to apply a vaccine to the population to reduce the viral spread, according to the WHO there are 23 projects in clinical phase stage III, such as vaccines: ChadOx1, nCov-19, Gam-COVID-Vac, CoronaVac that show promising results in research published by The Lancet Infection Diseases journal, for which we consider correlating the three vaccines and determining which is safer, generates greater immunogenicity and less reactogenicity in volunteer participants, for which we conducted a review bibliography and a meta-analysis of high impact scientific articles, concluding that the three vaccines generate a rapid and intense immune response against SARS-CoV-2, neutralizing antibodies had elevated titers in participants at 28 days, who increased and remained stable with a second dose, although each of them have been tested in different numbers and populations , applying recombinant adenoviral vectors and chemically inactivated virions with adjuvant and placebo for which they are totally different but with the same purpose to generate memory antibodies against SARS-
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