Disturbances of some blood biomarkers caused by titanium dioxide nanoparticles and mitigating role of garlic oil
Keywords:
Hematological parameters, nanoparticles, garlic oilAbstract
Employing nanoparticles in many consumer industries makes them questionable in terms of safety for human health. The purpose of this experimental study was to investigate the harmful effects of titanium dioxide nanoparticles on some hematological parameters, and then evaluate the ameliorated role of garlic oil. This study was conducted on 28 male rats, they were divided into 4 groups as follows: Con, which included healthy animals used as control. Tio2-N, which included rats poisoned with titanium dioxide nanoparticles. Tio2-N + Gar contained intoxicated rats with a combined treatment with garlic oil. Gar, included rats supplied with garlic oil only. After collecting blood from the sacrificed animals, blood tests were performed. Rats dosed with Tio2-N showed a clear reduce in red blood cell count, hemoglobin concentration, mean body size, mean muscle hemoglobin, mean muscle hemoglobin concentration, hematocrit value, and platelet count, versus a significant increase in white blood cell count compared to the control animals. However, with the co-administration of garlic oil with Tio2-N, a clear improvement in blood disorders was observed. Thus, garlic oil demonstrated its attenuating effect against Tio2-N -induced hematological changes in a rat model.
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