Early predictors and prognostication of children chronic kidney disease in the conditions of environmental disability

Resumen

The kidneys do not have a direct connection withexternal agents, but the elimination of a varietyof harmful environmental substances fromthe human body mainly occurs through this organ. At thesame time, the kidneys experience a significant functionalload, which can be realized in the clinical course, and inthe occurrence of kidney disease. The goal of our studywas to identify early predictors of diagnosis and predictionof children chronic kidney disease (CKD) in conditions ofenvironmental distress. The frequency, clinical and laboratorycharacteristics of chronic kidney disease were studiedamong 460 children from the industrial zone, betweenthe ages of birth and 18 years old (girls - 258 and boys- 202). All children were treated in the nephrology departmentof the regional children’s clinical hospital in theperiod from 2015 to 2017. We have identified three riskgroups for the development of children CKD in conditionsof environmental distress: the “high risk” group is an unfavorableprognosis group, the “medium risk” group is“attention group” and the “minimal risk” group. The revealedfeatures of children CKD of the main region indicatepronounced functional disorders and changes in thestructure of the renal tissue, which is caused by prolongedcontact with polymetallic dust. The nature of the revealedfeatures of children CKD of the main region indicates theintensity of the process of adaptation of the organism toadverse environmental factors and the predominant latentand low manifestation course of the disease.