Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/8804
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| Title: | Couepia paraensis: Estudio fitoquímico, ensayos de citotoxicidad y de inhibición de la glucosa-6-fosfatasa |
| Authors: | CABRERA, Gustavo GUARAMATO, María Alexandra RODRÍGUEZ, Miguel MÉNDEZ, Jeannette RODRÍGUEZ-ORTEGA, Morella CARVAJA, Zaida GONZÁLEZ-MUJICA, Freddy |
| Keywords: | Couepia paraensis, triterpenes, flavonoids, cytotoxicity, glucose-6-phosphatase |
| Issue Date: | 7-Apr-2015 |
| Abstract: | From the cholroform extract of the aerial parts of Couepia paraensis the triterpenes β-sitosterol1, betulinic acid acetate 2, and oleanolic acid acetate 3, were isolated. Six triterpenes from the chloroform-methanol, acids: oleanolic 4, pomolic 5, ursolic 6, betulinic 7, 6-β-hydroxybetulínic 8. Additionally from the methanolic extract three flavonoids were isolated: mricetin 9, quercetin 10 y rutina 11. The chloroform and chloroform-methanol extracts were not citotoxic at concentration of 2,5 and 3,1 μg / ml respectively after 24 hours of incubation. The methanol extract was found to be harmless to a concentration of 50 μg / ml, both at 24 hours (LD50 = 10.77 μg / ml) and 120 hours (LD50 = 28.86 μg / ml) of incubation. Only the methanol extract showed significant inhibition (41%) of the activity of G-6-Pase in intact microsomes without affecting the activity of the enzyme in microsomes broken. |
| URI: | http://hdl.handle.net/10872/8804 |
| ISSN: | 0717 7917 |
| Appears in Collections: | Artículos Publicados |
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