Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/7266
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| Title: | Trypanosoma cruzi III from armadillos (Dasypus novemcinctus novemcinctus) from Northeastern Venezuela and its biological behavior in murine model. Risk of emergency of Chagas’ disease |
| Authors: | Morocoima, Antonio Carrasco, Hernan Herrera Cabrera, Leidi Maira Boadas, Johanna Chique, Jose |
| Keywords: | Armadillo (Dasypus novemcinctus TcIII PCR–RFLP Venezuela |
| Issue Date: | 1-Aug-2012 |
| Publisher: | Elsevier. Experimental Parasitology |
| Citation: | Experimental Parasitology 132 (2012) 341–347 |
| Abstract: | Trypanosoma cruzi, etiological agent of Chagas’ disease, was isolated from armadillos (Dasypus novemcinctus novemcinctus) captured in rural communities Northeastern Venezuela from Nueva Esparta State (no endemic for Chagas’ disease), Monagas and Anzoátegui States (endemics). The isolates, genetically typed by PCR–RFLP as belonging to the TcIII DTU, have demonstrated in murine model heterogenic parasitemia, mortality and histotropism with marked parasitism in cardiac, skeletal, and smooth myocytes that showed correlation with lymphobasophilic inflammatory infiltrates. Our finding of T. cruzi infected armadillos in Isla Margarita (Nueva Esparta State), together with reports of triatomine vectors in this region, the accentuated synanthropy of armadillos, intense economic activity, migration due to tourism and the lack of environmental education programs all of them represent risks that could cause the emergence of Chagas’ disease in this area. This is the first report of the TcIII DTU in Northeastern Venezuela, thus widening the geographic distribution of this DTU. |
| URI: | http://hdl.handle.net/10872/7266 |
| Appears in Collections: | Artículos Publicados |
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