Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/5634
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| Title: | Antibody Responses and Resistance against Ascaris lumbricoides Infection among Venezuelan Rural Children: The Influence of Ethnicity |
| Authors: | Hagel, Isabel Cabrera, Maira Buvat, Erika Gutierrez, Loana Santaella, Carlos Borges, Rafael Infante, Benito Salas, Carolina Barrios, Yelitza |
| Keywords: | IgE IgG4 Amerindians |
| Issue Date: | 3-May-2008 |
| Publisher: | Journal Tropical Pediatrics |
| Citation: | J Trop pediatr |
| Series/Report no.: | vol 54;5 |
| Abstract: | We studied the production of anti parasite antibodies and the resistance against A. lumbricoides infection among the school population of three different Venezuelan ethnic groups: Warao Amerindians, Afro- Americans and white ‘Creole’ descendents. The prevalence and intensity of A. lumbricoides were determined before and after 1 year of anthelminthic treatment. Parasitic loads were associated to pre-treatment serum levels of anti A. lumbricoides IgE and IgG4 antibodies. The intensity of the infection and the proportion of re-infected children were significantly lower (p<0.0001) among the Warao Amerindians, exhibiting higher levels of IgE (p<0.0001) and lower levels of IgG4 (p<0.0001) compared to their non-Amerindian counterparts. IgE levels correlated inversely with the proportion of re-infected children, whereas the levels of IgG4 were positively associated. These results suggest that ethnicity may influence the balance of IgE/IgG4 levels, modulating the intensity of A. lumbricoides and the resistance to the infection. |
| Description: | En este trabajo se demuestra que diferencias en la produccion de anticuerpos especificos frente a Ascaris lumbricoides entre la poblacion infantil de diferentes grupos etnicos de venezuela difieren se relacionan con diferencias en la resistencia frente a la infeccion. |
| URI: | http://hdl.handle.net/10872/5634 |
| ISSN: | 0142-6338 |
| Appears in Collections: | Artículos Publicados |
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