Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/4900
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| Title: | Scorpions from the primeval subgenus Archaeotityus produce putative homologs of Tityus serrulatus toxins active on voltage-gated sodium channels |
| Authors: | Borges, Adolfo Jowers, Michael J. Bónoli, Stéfano De Sousa, Leonardo |
| Keywords: | Tityus clathratus Tityus serrulatus Venezuela Scorpion toxins |
| Issue Date: | 30-Nov-2012 |
| Publisher: | Journal of Venomous Animals and Toxins including Tropical Diseases |
| Citation: | J. Ven. Animals Tox. incl. Trop. Dis. 18 (2012), 432-440 |
| Series/Report no.: | 18;4 |
| Abstract: | It has been proposed that the subgenus Archaeotityus comprises the most ancient species group within the medically important scorpion genus Tityus. cDNA encoding sodium-channel active toxins from the type species of this subgenus, Tityus clathratus (central Venezuela), have been isolated and sequenced. Two cDNAs were retrieved that encoded 61 amino acid-long putative neurotoxins named Tcl1 and Tcl2. Sequence identity was highest (87%) when both were compared with β-toxin Ts1 from the Brazilian scorpion Tityus serrulatus and its homologs from T. bahiensis, T. stigmurus, and T. costatus. A Bayesian analysis indicated statistical support for the grouping of T. clathratus Tcl1 and Tcl2 with Brazilian gamma-like β-toxins, reinforcing previous phylogenetic studies which suggested an evolutionary relationship between the subgenus Archaeotityus and scorpion species inhabiting southeast South America belonging to the subgenus Tityus. |
| URI: | http://hdl.handle.net/10872/4900 |
| ISSN: | 1678-9199 |
| Appears in Collections: | Artículos Publicados |
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