Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/4515
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| Title: | Polymorphism in Tumor Necrosis Factor Genes Associated with Mucocutaneous Leishmaniasis |
| Authors: | Cabrera, Maira Shaw, Marie- Anne Sharples, Claire Williams, Hazel Castés, Marianella Convit, Jacinto Blackwell, Jenefer M |
| Keywords: | American cutaneous leishmaniasis TNF-alpha polimorphisms HLA-DRb susceptibility |
| Issue Date: | Nov-1995 |
| Publisher: | Journal of Experimental Medicine |
| Series/Report no.: | Vol.182; |
| Abstract: | Recent studies have shown that mucocutaneous leishmaniasis (MCL), a severe and debilitating form of American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis infection, is accompanied by high circulating levels of tumor necrosis factor (TNF)-oL. Analysis of TNF polymorphisms in Venezuelan ACL patients and endemic unaffected controls demonstrates a high relative risk (RR) of 7.5 (P <0.001) of MCL disease in homozygotes for allele 2 of a polymorphism in intron 2 of the TNF-[3 gene, especially in females (RR = 9.5; P <0.001) compared with males (RR = 4; P <0.05). A significantly higher frequency (P <0.05) of allele 2 at the -308-basepair TNF-c~ gene polymorphism was also observed in MCL patients (0.18) compared with endemic control subjects (0.069), again associated with a high relative risk of disease (RR = 3.5; P <0.05) even in the heterozygous condition. Because both the TNF-c~ and TNF-[3 polymorphisms have previously been linked with functional differences in TNF-oL levels, these data suggest that susceptibility to the mucocutaneous form of disease may be directly associated with regulatory polymorphisms affecting TNF-~x production. |
| URI: | http://hdl.handle.net/10872/4515 |
| ISSN: | 0022-1007 |
| Appears in Collections: | Artículos Publicados |
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