Synthesis of [(7-Chloroquinolin-4-yl)amino]chalcones: Potential Antimalarial and Anticancer Agents

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DC Field	Value	Language
dc.contributor.author	Ferrer, Rosa	-
dc.contributor.author	Lobo, Gricela	-
dc.contributor.author	Gamboa, Neira	-
dc.contributor.author	Rodrigues, Juan	-
dc.contributor.author	Abramjuk, Claudia	-
dc.contributor.author	Jung, Klaus	-
dc.contributor.author	Lein, Michael	-
dc.contributor.author	Charris, Jaime E.	-
dc.date.accessioned	2011-06-27T18:39:45Z	-
dc.date.available	2011-06-27T18:39:45Z	-
dc.date.issued	2009-10-14	-
dc.identifier.issn	0036-8709	-
dc.identifier.uri	http://hdl.handle.net/10872/306	-
dc.description.abstract	[(7-Chloroquinolin-4-yl)amino]chalcone derivatives derived from the corresponding 3- or 4-[(7-chloroquinolin-4-yl)amino]acetophenone were synthesized and evaluated for in vitro antimalarial and anticancer activity. The most active compounds 12, 13, 15, 17 and 19 from the 3-substituted series displayed inhibitory values against heme cristallization in the range of 93.14 ± 1.74 – 94.93 ± 1.50 % as an antimalarial mechanism and cytotoxic effect with IC50 values of 7.93 ± 2.05, 7.11 ± 2.06 and 6.95 ± 1.62 μg/mL for 13, 17 and 19 respectively against humane prostate LNCaP tumor cells	es_VE
dc.publisher	Sci Pharm	es_VE
dc.relation.ispartofseries	77:;725–741	-
dc.subject	Malaria	es_VE
dc.subject	CQ	es_VE
dc.subject	β-Hematin	es_VE
dc.subject	Cancer	es_VE
dc.subject	Prostate	es_VE
dc.title	Synthesis of [(7-Chloroquinolin-4-yl)amino]chalcones: Potential Antimalarial and Anticancer Agents	es_VE
dc.type	Article	es_VE
Appears in Collections:	Artículos Publicados

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