Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/2366
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| Title: | Plasmodium berghei: In vitro and in vivo activity of dequalinium |
| Authors: | Rodrigues, Juan R. Gamboa, Neira |
| Keywords: | Hematinines Bisquinolines CQ chloroquine DQ dequalinium Globin Heme LEP eupeptin Malaria P. berghei Plasmodium berghei DMSO dimethyl sulfoxide Globin GSH glutathione Heme PEP pepstatin PBS RBC phosphate-buVered saline red blood cells SDS–PAGE sodium dodecyl sulfate polyacrylamide gel electrophoresis |
| Issue Date: | 14-Jan-2013 |
| Abstract: | Bisquinoline compounds have exhibited remarkable activity in vitro and in vivo against Plasmodium parasites by inhibition of heme detoxiWcation. We have tested the ability of dequalinium 1,1 -(1,10 decanediyl)bis(4-amino-2-methylquinoline), a known antimicrobial agent, to inhibit -hematin synthesis using a non-emzymatic colorimetric assay and globin proteolysis by electrophoretic analysis (SDS– PAGE-15%). Dequalinium was able to inhibit both processes in vitro with close correlation to a murine malaria model, reducing parasitemia levels, prolonging the survival time post-infection and curing 40% of infected mice using a combination therapy with a loading dose of chloroquine. These results conWrm that dequalinium is a promising lead for antimalarial drug development. © 2006 Elsevier Inc. All rights reserved. |
| URI: | http://hdl.handle.net/10872/2366 |
| Appears in Collections: | Artículos Publicados |
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