Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/183
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| Title: | INCREASED ATRIAL NATRIURETIC PEPTIDE (6-33) BINDINC SITES IN THE SUBFORNICAL ORGAN OF WATER DEPRIVED AND BRAITLEBORO RATS |
| Authors: | Saavedra, Juan M. Israel, Anita Correa, Fernando KURIHARA, MIASAKI |
| Issue Date: | 1986 |
| Publisher: | PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE |
| Series/Report no.: | ;182, 559_563 (1986) |
| Abstract: | Binding sites for rat atrial natriuretic peptide (6-33) (ANP) were quantitated in the subfornical organ of chronically dehydrated homozygous Brattleboro rats unable to synthesize vasopressin; heterozygous Brattleboro rats, their contro'ls, Long tvans rats and Long Evans rats after 4 days of lrater,qejrivation. Brain sections were incubated in the presence of r¿)l-ANP and the results analyzed by autoradiogr?ehy coupled to computerized microdensitometry and coflparison to IZ5l-standards. Brattleboro rats and water deprived Long Evans rats presented a higher number of ANP binding sites than their noñnally hydrated controls. our results suggest a role of ANP binding sites in the subfornical organ in the central requlation of fluid balance and vasopressin secretion. |
| URI: | http://hdl.handle.net/10872/183 |
| Appears in Collections: | Artículos Publicados |
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