Magnetic water-soluble rhamnose-coated Mn 1-X Co X Fe 2 O 4 nanoparticles as potential heating agents for hyperthermia

Abstract

Water-soluble rhamnose-coated mixed manganese-cobalt ferrite nanoparticles Mn(1-X)Co(X) Fe(2)O(4) (0≤x≤1) specifically designed as magnetic fluid hyperthermia heat mediators were successfully synthesized by thermal decomposition of molecular precursors in a size range between 6 - 12 nm. The formation of the nanoparticles (NPs) and modification of their surface with a rhamnose derivative were confirmed by FTIR spectroscopy, X-ray diffraction (XRD) and transmission electronic microscopy (TEM). Electron Paramagnetic Resonance (EPR) was used to study the temperature dependence of the magnetic behavior of the samples coated with rhamnose. The magnetic properties being investigated at 2.5 and 300 K include blocking temperature (T B ), saturation magnetization (M s ), remnant magnetization (M R ) and coercive field (Hc). The magnetic properties carried out at 300 K show the increase of the saturation magnetization (M s ) at the Mn 2+ ratio x = 0.75. The variation of SAR and magnetization of Mn 1-X Co X Fe 2 O 4 with Mn 2+ ratio shows similar dependence. The advantage of the designed rhamnose-coated Mn 1-X Co X Fe 2 O 4 system lies in the fact that versatile combinations of Mn 2+ and Co 2+ components can facilitate the tuning of the magnetic properties to optimize the Specific Absorption Rate (SAR).