Saber UCV
Repositorio Institucional
Repositorio Institucional
Please use this identifier to cite or link to this item:
https://saber.ucv.ve/handle/10872/1711
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| Title: | Experimental Leishmaniasis: The glibenclamide-triggered decrease in parasite growth correlates with changes in macrophage features. |
| Authors: | Ponte-Sucre, Alicia Figarella, Katherine Moll, Heidrun |
| Keywords: | Macrophages Infectivity Glibenclamide |
| Issue Date: | 28-Aug-2012 |
| Series/Report no.: | Inmunopharmacology and Immunotoxicology;23: 477-486, 2001 |
| Abstract: | Previous studies from our laboratories revealed the susceptibility of Leishmania sp. to glibenclamide (GLIB), a potassium channel blocker which selectively interacts with adenosine-binding-cassette transporters. In the present work, we analyzed whether the drug sensitivity of intracellular amastigotes correlates with changes in macrophage features that are related to their function as antigen-presenting cells. We provide evidence that in BALB/c murine macrophages, GLIB induced a decrease in the interferon-gamma-stimulated expression of major histocompatibility complex class II molecules and the co-stimulatory molecule CD86 (B7-2). Furthermore, it caused a decrease in the interleukin-1 secretion by macrophages. The data indicate that the treatment with GLIB inhibits the Th2 development and polarizes macrophage functions towards the induction of a protective Th1 response. |
| URI: | http://hdl.handle.net/10872/1711 |
| ISSN: | 0892-3973 |
| Appears in Collections: | Artículos Publicados |
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