Lymphocyte Subset Diversity in Idiopathic CD4+ T Lymphocytopenia

Abstract

The clinical and public health importance of CD4+ T lymphocytopenia without human immunodeficiency virus infection is still unclear. We describe herein two new human immunodeficiency virus-negative patients with low numbers of peripheral CD4+ T cells and opportunistic infections (cerebral toxoplasmosis and tuberculosis plus extrapulmonary histoplasmosis). The low numbers of CD4+ CD29+ memory cells, the high percentage of γδ T-cell receptor cells, and the recovery of CD4+ cells after treatment were remarkable.