Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/14573
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| Title: | Highly Endemic Human T-Lymphotropic Virus Type II (HTLV-II) Infection in a Venezuelan Guahibo Amerindian Group |
| Authors: | Leon-Ponte, Matilde Noya, Oscar Bianco Colmenares, Nicolás E. Echeverría de Perez, Gloria |
| Keywords: | HTLV-II Amerindians Polymerase chain reaction- Venezuela human T-cell lymphotropic virus immunofluorescence mononuclear cell pol gene |
| Issue Date: | 1996 |
| Publisher: | Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology |
| Series/Report no.: | Vol. 13;No. 3 pp 281-286 |
| Abstract: | Sera from 166 Guahibo Indians (55% of the population) living in southwest Venezuela were screened by enzyme-linked immunoassay for antibodies to human T-cell lymphotropic virus (HTLV) I and II. Positive samples were confirmed by immunofluorescence and Western blot. Forty-one Guahibos (24.8%) were found to be seropositive. Polymerase chain reaction (PCR) analysis of proviral DNA in mononuclear cell lysates revealed the virus to be HTLV-II. Prevalence increased with age, and sexual contact with HTLV-II-seropositive partners was identified as a risk factor for infection. PCR amplification of a region of the pol gene, utilizing the primer pair SK110/SK111, with subsequent digestion of the 140-base-pair amplification products with HinfI and MseI restriction enzymes, showed an HTLV-II subtype-b restriction pattern in all cases. These data suggest that the substrain infecting this Guahibo community belongs to the b subtype, the most frequent among Paleo-Amerindian populations. |
| URI: | http://hdl.handle.net/10872/14573 |
| ISSN: | 1077-9450 |
| Appears in Collections: | Artículos Publicados |
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