Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/14462
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| Title: | IMMUNOPATHOLOGY OF HUMAN SCHISTOSOMIASIS MANSONI. I. IMMUNOMODULATORY INFLUENCES ON T CELL FUNCTION. |
| Authors: | Aldrey, Oscar Alarcon de Noya, Belkisyole Machado, I. Noya, Oscar Bianco Colmenares, Nicolás E. Perez, G . E. |
| Keywords: | Immunoregulatíon T cells Human schistosomiasis Cell mediated immune response chronic Schistosoma mansoni mononuclear cells cell preparations precultured cells |
| Issue Date: | 1988 |
| Publisher: | Revista do Instituto de Medicina Tropical de São Paulo |
| Series/Report no.: | Vol. 30;No. 6 pp 393-399 |
| Abstract: | Cell mediated immune response was studied in patients with recent and chronic Schistosoma mansoni infection. Precultured peripheral mononuclear cells showed significantly higher responses to S. mansoni adult worm antigen (SAWA) when corn pared to fresh cell preparations. The addition of each patient serum to the precultured cells reactions to SAWA or recall antigens demonstrated a strong inhibitory serum action, which was also noted on allogeneic cells derived from healthy subjects. The CD4 subset was the main responding cell t o SAWA being this reactivity highly suppressed by the presence of the monocyte-macrophage accessory cells. We stressed the simultaneous inhibitory action of humoral and cellular factors on the specific cell response to S. mansoni. |
| URI: | http://hdl.handle.net/10872/14462 |
| ISSN: | 1678-9946 |
| Appears in Collections: | Artículos Publicados |
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