Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/14220
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| Title: | Seronegative spondyloarthropathies and HLA antigens in a Mestizo population |
| Authors: | Pérez R., Gloria E. Paul M., Hernándo Bianco Colmenares, Nicolás E. Abadí, Isaac |
| Keywords: | HLA-A antigens Seronegative Spondyloarthropathies Mestizo population ankylosing spondylitis spondylitic lesion |
| Issue Date: | 1984 |
| Publisher: | Tissue Antigens |
| Series/Report no.: | Vol. 23;No. 2 pp 111-112 |
| Abstract: | HLA-A and -B antigens incidence were investigated in 100 cases of Seronegative Spondyloarthropathies and in 303 control individuals of a Venezuelan Mestizo population. Significative increased incidence of B27 was found among 69% of patients with ankylosing spondylitis and 68% with Reiter syndrome being the incidence in the control group of 2.9%. The B27 negative patients showed 40.4% positivity for Bw35, with spondylitic lesion in 12 ou t of 17 cases. Our results question the applicability of B27 as diagnostic criteria in the Mestizo patients bearers of a Seronegative Spondyloarthropathy and suggest the need to investigate further the role of antigens of the B locus in the pathophysiology of these clinical entities. |
| URI: | http://hdl.handle.net/10872/14220 |
| ISSN: | 1399-0039 |
| Appears in Collections: | Artículos Publicados |
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