Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/14063
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| Title: | Biological screening of plants of the Venezuelan Amazons |
| Authors: | Jiménez, G. Hasegawa, Masahisa Rodríguez, María del C. Estrada, Omar Méndez, Jeannette Castillo, Anibal González-Mujica, F. Motta, N. Vásquez, J. Romero-Vechione, Eduardo |
| Keywords: | Amazonian plants Brine shrimp lethality test Cardiovascular activity Glucose-6-phosphatase Biological screening |
| Issue Date: | 2001 |
| Publisher: | Journal of Ethno-Parmacology |
| Citation: | Journal of Ethnopharmacology 77 (2001) 77–83 |
| Abstract: | A total of 21 extracts derived from 17 different plant species collected in Venezuelan Amazons have been tested for the following biological activities: cardiovascular activity, brine shrimp lethality, and inhibitory effects on the hydrolysis of glucose-6-phosphate in intact and disrupted microsomes. Eight extracts diminished rat blood pressure with or without changes in heart rate. The fruit extract of Swartzia leptopetala and the leaf and twig extract of Connarus lambertii resulted in death of experimental animals. The majority of extracts (17 extracts) showed significant toxicity against Artemia salina. Concerning the hydrolysis of glucose-6-phosphate, better inhibitory effects were observed in intact microsomes than in disrupted ones for all the extracts, suggesting that these extracts intervene with variable potency in glucose-6-phosphate transport through the microsomal membrane. |
| URI: | http://hdl.handle.net/10872/14063 |
| ISSN: | 0022-3573 |
| Appears in Collections: | Artículos Publicados |
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