Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/13853
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| Title: | Intracellular topography of immunoreactlve gastrin demonstrated using electron immunocytochemistry. |
| Authors: | Varndell, I.M. Harris, A. Tapia, Félix J. Yanaihara, N. De Mey, J. Bloom, S.R Polak, J.M. |
| Keywords: | Gastrin (G ) producing cells assisted morphometry electron-dense electron-lucent |
| Issue Date: | Jul-1983 |
| Publisher: | Experientia |
| Series/Report no.: | Vol. 15;Nº 39 |
| Abstract: | Gastrin (G )-producing cells from the mammalian gastric antrum have been investigated using computer-assisted morphometry and a novel double colloidal gold-labeled-immunoglobulin electron immunocytochemical procedure. Correlation analysis of human antral G-cells indica tes (p < 0.001) that a single population of granules exists with small (160 nm) electron-dense and large (240 nm) electron-lucent forms representing the extremes. Non-crossreacting region-specific antisera have been used to visualize G-17 and G34 (progastrin) to the small electron-dense granules and G-17 lo the other intermediate forms. From the results we propose a topographic segregation of immunoreactive gastrins within 2 apparently distinct granule subclasses and suggest that this may represent the pathway of granule maturation. |
| URI: | http://hdl.handle.net/10872/13853 |
| ISSN: | 0014-4754 |
| Appears in Collections: | Artículos Publicados |
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