Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/13208
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| Title: | LEUKOCYTE SUBSETS IN THE GRANULOMATOUS RESPONSE PRODUCED AFTER INOCULATION WITH MYCOBACTERIUM LEPR 4E BCG IN LEPROMATOUS PATIENTS |
| Authors: | Gross, Ana Weiss, Eduardo Tapia, Félix J. Aranzazu, Nacarid Gallinoto, María E. Convit, Jacinto |
| Keywords: | Leukocyte subsets granulomatous Mycobacterium leprae lepromatous leprosy patients monoclonal antibodies immunoperoxidase technique |
| Issue Date: | 1988 |
| Publisher: | The American Journal of Tropical Medicine and Hygiene |
| Series/Report no.: | Vol. 38;Nº 3 |
| Abstract: | Leukocyte subsets present in the granulomatous response produced after the inoculation of a mixture of Mycobacterium leprae and BCG in lepromatous leprosy patients Were Characterized in situ using monoclonal antibodies and an immunoperoxidase technique. The granuloma produced after M. leprae -BCG Showed a distribution like pattern to tuberculoid granulomas . T lymphocytes bearing the CD8 phenotype (T cytotoxic / suppressor) Were sequestered to the periphery of the epithelioid tubercles and T helper-inducer CD4 + lymphocytes infiltrate the Were distributed THROUGHOUT. Langerhans cells CD1 + Were Increased in the epidermis, dermis and in They Were localized mainly in the mantle surrounding the granuloma . Most of the dermal infiltrate produced after the inoculation or M. leprae -BCG expresses the HLA antigen -DR. Similarly, keratinocytes Were MOST Also positive to this MHC antigen. The granulomatous response to BCG was similar to the inoculation of a mixture of M. leprae -BCG, however acid-fast bacilla Were still present. The inoculation of M. leprae produced by macrophage granuloma With No clearing of the bacilla Which Resembles the lepromatous leprosy granuloma. |
| URI: | http://hdl.handle.net/10872/13208 |
| ISSN: | 0002-9637 |
| Appears in Collections: | Artículos Publicados |
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