Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/12074
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| Title: | IMMUNOPATHOLOGY OF HUMAN SCHISTOSOMIASIS MANSONI. II. NK ACTIVITY AND STIMULATION BY SPECIFIC ANTIGEN |
| Authors: | BENARROCH, O. Noya, Oscar Alarcon de Noya, Belkisyole BLANCA, I. Bianco Colmenares, Nicolás E. |
| Keywords: | Natural Killer cells S. mansoni |
| Issue Date: | 1988 |
| Publisher: | Rev. Inst. Med. trop. Sao Paulo |
| Series/Report no.: | vOL. 30;6 |
| Abstract: | Sixteen S. mansoni infected and untreated patients (5 with recent infection and 11 with chronic disease) were evaluated for their in v i t r o natural killer ( N K ) activity against the N K sensitive target K562 cell line. N K levels in 9 out of 11 patients (82%) w i th chronic disease were significantly lower (mean = 15 ± 6%), compared with patients recently infected (mean = 41 ± 9% p < 0.001) and with the control group (mean = 38 ± 13% p < 0.001). However, both patients and controls N K activity was stimulated by soluble adult worm antigens (SAWA) , indicating that N K function even in the chronic stage of the infection is able to respond to the parasite antigens. Thes e results suggest the possibility of N K cell participati on as effector mechanism against S . mansoni. |
| URI: | http://hdl.handle.net/10872/12074 |
| Appears in Collections: | Artículos Publicados |
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