Advances and perspectives in buccal films applied in dentistry
Keywords:
buccal films, polymers, bilayer films, oral mucosa, odontologyAbstract
Buccal films are pharmaceutical forms developed from polymers of natural, semi-synthetic or synthetic origin, which are arranged in the form of thin films capable of adhering to the buccal, sublingual or lingual mucosa, allowing the administration of drugs with local or systemic effect. The aim of this study is to compile, characterize and analyze relevant and updated information on buccal films and their therapeutic applications in the dental field. A bibliographic review was carried out to deepen knowledge about the applicability of these formulations in oral pathologies. Buccal films are innovative pharmaceutical forms that are in the research phase, they improve the conditions of drug administration, since they avoid the hepatic first-pass effect, enzymatic inactivation, as well as the handling and comfort in their use. These formulations have proven to have good properties in the treatment of different pathologies at stomatological level, such as periodontal disease, herpetic and fungal infections, as well as in pain management and administration of local anesthesia
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References
Alvarracin-Baculima M, Cuenca-León K, Pacheco-Quito EM. Antimicrobial Nanoparticles in Dentistry: State of the art. Arch Venez Farmacol y Ter [Internet]. 2021 [citado 2022 Feb 1]; 40(8):839–47. Disponible en: http://doi.org/10.5281/zenodo.5791388
Ricco V, Virga MC, Aguzzi A. Problemas relacionados a los medicamentos: Farmacovigilancia en la profesión odontológica. Arch Venez Farmacol y Ter [Internet]. 2012 [citado 2022 Feb 1]; 31(2):37–43. Disponible en: http://saber.ucv.ve/ojs/index.php/rev_aavft/article/view/1781
Preis M, Woertz C, Kleinebudde P, Breitkreutz J. Oromucosal film preparations: classification and characterization methods. Expert Opin Drug Deliv [Internet]. 2013 [citado 2022 Feb 4]; 10(9):1303–17. Disponible en: http://www.tandfonline.com/doi/full/10.1517/17425247.2013.804058
Lindert S, Breitkreutz J. Oromucosal multilayer films for tailor-made, controlled drug delivery. Expert Opin Drug Deliv [Internet]. 2017 [citado 2022 Feb 4]; 14(11):1265–79. Disponible en: https://www.tandfonline.com/doi/full/10.1080/17425247.2017.1276899
Montenegro-Nicolini M, Morales JO. Overview and Future Potential of Buccal Mucoadhesive Films as Drug Delivery Systems for Biologics. AAPS PharmSciTech [Internet]. 2017 [citado 2022 Feb 4]; 18(1):3–14. Disponible en: http://link.springer.com/10.1208/s12249-016-0525-z
Hanif M, Zaman M, Chaurasiya V. Polymers used in buccal film: a review. Des Monomers Polym [Internet]. 2015 [citado 2022 Feb 4]; 18(2):105–11. Disponible en: https://www.tandfonline.com/doi/full/10.1080/15685551.2014.971389
Silva BMA, Borges AF, Silva C, Coelho JFJ, Simões S. Mucoadhesive oral films: The potential for unmet needs. Int J Pharm [Internet]. 2015 [citado 2022 Feb 4]; 494(1):537–51. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0378517315301356
van der Mei HC, White DJ, Atema-Smit J, Geertsema-Doornbusch GI, Busscher HJ. Surface thermodynamic homeostasis of salivary conditioning films through polar–apolar layering. Clin Oral Investig [Internet]. 2012 [citado 2022 Feb 4]; 16(1):109–15. Disponible en: http://link.springer.com/10.1007/s00784-011-0514-2
Li A, Khan IN, Khan IU, Yousaf AM, Shahzad Y. Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis. Drug Des Devel Ther [Internet]. 2021[citado 2022 Feb 14]; 15:3937–52. Disponible en: https://www.dovepress.com/gellan-gum-based-bilayer-mucoadhesive-films-loaded-with-moxifloxacin-h-peer-reviewed-fulltext-article-DDDT
Tejada G, Barrera MG, Piccirilli GN, Sortino M, Frattini A, Salomón CJ, et al. Development and Evaluation of Buccal Films Based on Chitosan for the Potential Treatment of Oral Candidiasis. AAPS PharmSciTech [Internet]. 2017[citado 2022 Feb 14]; 18(4):936–46. Disponible en: https://link.springer.com/article/10.1208/s12249-017-0720-6
Vecchi CF, Said dos Santos R, Bassi da Silva J, Rosseto HC, Sakita KM, Svidzinski TIE, et al. Development and in vitro evaluation of buccal mucoadhesive films for photodynamic inactivation of Candida albicans. Photodiagnosis Photodyn Ther [Internet]. 2020 [citado 2022 Feb 20];32(May):101957. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1572100020303112
Rana P, Murthy RSR. Formulation and evaluation of mucoadhesive buccal films impregnated with carvedilol nanosuspension: a potential approach for delivery of drugs having high first-pass metabolism. Drug Deliv [Internet]. 2013[citado 2022 Feb 20]; 20(5):224–35. Disponible en: http://www.tandfonline.com/doi/full/10.3109/10717544.2013.779331
Gajdošová M, Vetchý D, Muselík J, Gajdziok J, Juřica J, Vetchá M, et al. Bilayer mucoadhesive buccal films with prolonged release of ciclopirox olamine for the treatment of oral candidiasis: In vitro development, ex vivo permeation testing, pharmacokinetic and efficacy study in rabbits. Int J Pharm [Internet]. 2021 [citado 2022 Feb 20]; 592:120086. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0378517320310711
Saxena A, Tewari G, Saraf SA. Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon. Brazilian J Pharm Sci [Internet]. 2011 [citado 2022 Feb 20]; 47(4):887–97. Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400026&lng=en&tlng=en
Zhang C, Liu Y, Li W, Gao P, Xiang D, Ren X, et al. Mucoadhesive buccal film containing ornidazole and dexamethasone for oral ulcers: in vitro and in vivo studies. Pharm Dev Technol [Internet]. 2019 [citado 2022 Feb 20];24(1):118–26. Disponible en: https://www.tandfonline.com/doi/full/10.1080/10837450.2018.1428814
M. Farid R, Ming Wen M. Promote Recurrent Aphthous Ulcer Healing with Low Dose Prednisolone Bilayer Mucoadhesive Buccal Film. Curr Drug Deliv [Internet]. 2017 [citado 2022 Feb 20]; 14(1):123–35. Disponible en: http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1567-2018&volume=14&issue=1&spage=123
Ammar HO, Ghorab MM, Mahmoud AA, Shahin HI. Design and In Vitro/In Vivo Evaluation of Ultra-Thin Mucoadhesive Buccal Film Containing Fluticasone Propionate. AAPS PharmSciTech [Internet]. 2017 Feb 1 [citado 2022 Mar 1]; 18(1):93–103. Disponible en: https://link.springer.com/article/10.1208/s12249-016-0496-0
Alves TFR, Rios AC, Pontes K da S, Portella DL, Aranha N, Severino P, et al. Bilayer mucoadhesive buccal film for mucosal ulcers treatment: Development, characterization, and single study case. Pharmaceutics [Internet]. 2020 [citado 2022 Feb 20]; 12(7):1–24. Disponible en: https://www.mdpi.com/1999-4923/12/7/657
Desai KGH, Mallery SR, Holpuch AS, Schwendeman SP. Development and in vitro-in vivo evaluation of fenretinide-loaded oral mucoadhesive patches for site-specific chemoprevention of oral cancer. Pharm Res [Internet]. 2011 [citado 2022 Feb 25]; 28(10):2599–609. Disponible en: http://link.springer.com/10.1007/s11095-011-0489-3
Costa IDSM, Abranches RP, Garcia MTJ, Pierre MBR. Chitosan-based mucoadhesive films containing 5-aminolevulinic acid for buccal cancer’s treatment. J Photochem Photobiol B Biol [Internet]. 2014 [citado 2022 Feb 25]; 140:266–75. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1011134414002565
Ramineni SK, Cunningham LL, Dziubla TD, Puleo DA. Development of Imiquimod-Loaded Mucoadhesive Films for Oral Dysplasia. J Pharm Sci [Internet]. 2013 [citado 2022 Feb 25]; 102(2):593–603. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S002235491531220X
Li X-Q, Ye Z-M, Wang J-B, Fan C-R, Pan A-W, Li C, et al. Mucoadhesive buccal films of tramadol for effective pain management. Brazilian J Anesthesiol (English Ed [Internet]. 2017 [citado 2022 Feb 25]; 67(3):231–7. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S010400141630029X
Eleftheriadis GK, Monou PK, Bouropoulos N, Boetker J, Rantanen J, Jacobsen J, et al. Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing. J Pharm Sci [Internet]. 2020 [citado 2022 Feb 26]; 109(9):2757–66. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0022354920302719
Preis M, Woertz C, Schneider K, Kukawka J, Broscheit J, Roewer N, et al. Design and evaluation of bilayered buccal film preparations for local administration of lidocaine hydrochloride. Eur J Pharm Biopharm [Internet]. 2014 [citado 2019 Feb 26]; 86:552–61. Disponible en: http://dx.doi.org/10.1016/j.ejpb.2013.12.019
Ribeiro LNM, Franz-Montan M, Alcântara ACS, Breitkreitz MC, Castro SR, Guilherme VA, et al. Hybrid nanofilms as topical anesthetics for pain-free procedures in dentistry. Sci Rep [Internet]. 2020 [citado 2022 Feb 27]; 10(1):11341. Disponible en: http://www.nature.com/articles/s41598-020-68247-0
Kottke D, Majid H, Breitkreutz J, Burckhardt BB. Development and evaluation of mucoadhesive buccal dosage forms of lidocaine hydrochloride by ex-vivo permeation studies. Int J Pharm [Internet]. 2020 [citado 2022 Feb 26]; 581(2020):119293. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0378517320302775
do Couto RO, Cubayachi C, Calefi PL, Lopez RFV, Pedrazzi V, De Gaitani CM, et al. Combining amino amide salts in mucoadhesive films enhances needle-free buccal anesthesia in adults. J Control Release [Internet]. 2017 [citado 2022 Feb 26]; 266:205–15. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0168365917308830
Krampe R, Visser JC, Frijlink HW, Breitkreutz J, Woerdenbag HJ, Preis M. Oromucosal film preparations: points to consider for patient centricity and manufacturing processes. Expert Opin Drug Deliv [Internet]. 2016 [citado 2022 Feb 27]; 13(4):493–506. Disponible en: http://www.tandfonline.com/doi/full/10.1517/17425247.2016.1118048
Morales JO, McConville JT. Manufacture and characterization of mucoadhesive buccal films. Eur J Pharm Biopharm [Internet]. 2011 [citado 2019 Feb 28]; 77(2):187–99. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0939641110003176
Nair AB, Kumria R, Harsha S, Attimarad M, Al-Dhubiab BE, Alhaider IA. In vitro techniques to evaluate buccal films. J Control Release [Internet]. 2013 [citado 2022 Feb 27]; 166(1):10–21. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0168365912008267
Khan S, Boateng JS, Mitchell J, Trivedi V. Formulation, Characterisation and Stabilisation of Buccal Films for Paediatric Drug Delivery of Omeprazole. AAPS PharmSciTech [Internet]. 2015 [citado 2022 Feb 27]; 16(4):800–10. Disponible en: http://link.springer.com/10.1208/s12249-014-0268-7
Montenegro-Nicolini M, Reyes PE, Jara MO, Vuddanda PR, Neira-Carrillo A, Butto N, et al. The Effect of Inkjet Printing over Polymeric Films as Potential Buccal Biologics Delivery Systems. AAPS PharmSciTech [Internet]. 2018 [citado 2022 Feb 27]; 19(8):3376–87. Disponible en: http://link.springer.com/10.1208/s12249-018-1105-1
Kour P, Rath G, Sharma G, Goyal AK. Recent advancement in nanocarriers for oral vaccination. Artif Cells, Nanomedicine, Biotechnol [Internet]. 2018 [citado 2022 Feb 26]; 46(sup3):S1102–14. Disponible en: https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1533842
Abruzzo A, Vitali B, Lombardi F, Guerrini L, Cinque B, Parolin C, et al. Mucoadhesive Buccal Films for Local Delivery of Lactobacillus brevis. Pharmaceutics [Internet]. 2020 [citado 2022 Feb 26]; 12(3):241. Disponible en: https://www.mdpi.com/1999-4923/12/3/241
Prezotti FG, Siedle I, Boni FI, Chorilli M, Müller I, Cury BSF. Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery. Pharm Dev Technol [Internet]. 2020 [citado 2022 Feb 25]; 25(2):159–67. Disponible en: https://www.tandfonline.com/doi/full/10.1080/10837450.2019.1682608
Vea-Barragán AC, Castillo-Martínez NA, Serrano-Medina A, López-Maldonado EA, Meléndez-López SG, Cornejo-Bravo JM. Preparación de películas mucoadhesivas de complejos de polielectrólitos para la liberación de diacetato de clorhexidina. Rev Ciencias Tecnológicas [Internet]. 2020 [citado 2022 Feb 14]; 3(1):10–22. Disponible en: https://recit.uabc.mx/index.php/revista/article/view/2oba9
Bascones Martínez A, Figuero Ruiz E. Las enfermedades periodontales como infecciones bacterianas. Av en Periodoncia e Implantol Oral [Internet]. 2005 Dec [citado 2022 Feb 27]; 17(3):147–56. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1699-65852005000300004&lng=en&nrm=iso&tlng=en
López Silva MC, Diz-Iglesias P, Seoane-Romero JM, Quintas V, Méndez-Brea F, Varela-Centelles P. Actualización en medicina de familia: patología periodontal. Semer - Med Fam [Internet]. 2017 [citado 2022 Feb 4]; 43(2):141–8. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1138359316000848
Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, et al. Periodontitis and diabetes: a two-way relationship. Diabetologia [Internet]. 2012 Jan 6 [citado 2022 Mar 1]; 55(1):21–31. Disponible en: http://link.springer.com/10.1007/s00125-011-2342-y
Escobedo Muñoz JJ, Varela Castillo L, Chávez Romero PB, Becerra Sánchez A, Moreno García MA. Bacterias patógenas aisladas de teléfonos celulares del personal y alumnos de la Clínica Multidisciplinaria (CLIMUZAC) de la unidad Académica de Odontología de la UAZ . Arch Venez Farmacol y Ter [Internet]. 2012 [citado 2022 Feb 1]; 31(2):1–9. Disponible en: http://saber.ucv.ve/ojs/index.php/rev_aavft/article/view/1777
Reid G. Probiotics: definition, scope and mechanisms of action. Best Pract Res Clin Gastroenterol [Internet]. 2016 [citado 2022 Feb 25]; 30(1):17–25. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1521691815001651
Carrero González C, Navarro Quiroz E, Lastre-Amell G, Oróstegui-Santander M, González Peña G, Sucerquia A, et al. Dislipidemia como factor de riesgo cardiovascular: uso de probióticos en la terapéutica nutricional. Arch Venez Farmacol y Ter [Internet]. 2020 [citado 2022 Feb 25]; 39(1). Disponible en: https://doi.org/10.5281/zenodo.4068226
Otero Rey E, Peñamaría Mallón M, Rodríguez Piñón M, Martín Biedma B, Blanco Carrión A. Candidiasis oral en el paciente mayor. Av Odontoestomatol [Internet]. 2015 [citado 2022 Feb 24]; 31(3):135–48. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0213-12852015000300004&lng=en&nrm=iso&tlng=en
Jerez Puebla L, Fernández C, Perurena M, Rodríguez I, Martinez G. Susceptibilidad in vitro de candida spp. aisladas de la cavidad oral de pacientes VIH/sida a itraconazol, clotrimazol y ketoconazol. Arch Venez Farmacol y Ter [Internet]. 2012 [citado 2022 Feb 25]; 31(4):1–5. Disponible en: http://ve.scielo.org/scielo.php?script=sci_abstract&pid=S0798-02642012000400003&lng=pt&nrm=iso
Widener RW, Whitley RJ. Herpes simplex virus. In: Handbook of Clinical Neurology [Internet]. 1st ed. Elsevier B.V.; 2014. p.251–63. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/B9780444534880000110
De Clercq E. Antiviral drugs in current clinical use. J Clin Virol [Internet]. 2004 [citado 2022 Feb 24]; 30:115–33. Disponible en: https://doi.org/10.1016/j.jcv.2004.02.009
Pacheco-Quito E-M, Ruiz-Caro R, Rubio J, Tamayo A, Veiga M-D. Carrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes. Mar Drugs [Internet]. 2020 [citado 2022 Feb 24];18(5):249. Disponible en: https://www.mdpi.com/1660-3397/18/5/249
Huaccho-Rojas J, Balladares A, Yanac-Tellería W, Lidsey Rodríguez C, Villar-López M. Review of antiviral and immunomodulatory effects of herbal medicine with reference to pandemic COVID-19. Arch Venez Farmacol y Ter [Internet]. 2020 [citado 2022 Feb 1]; 39(6):1–13. Disponible en: https://www.revistaavft.com/images/revistas/2020/avft_6_2020/18_revision_del_efecto_antiviral.pdf
Markopoulos AK. Current Aspects on Oral Squamous Cell Carcinoma. Open Dent J [Internet]. 2012 [citado 2022 Feb 24]; 6(1):126–30. Disponible en: https://opendentistryjournal.com/VOLUME/6/PAGE/126/
Chin D, Boyle GM, Porceddu S, Theile DR, Parsons PG, Coman WB. Head and neck cancer: past, present and future. Expert Rev Anticancer Ther [Internet]. 2006 [citado 2022 Feb 25]; 6(7):1111–8. Disponible en: http://www.tandfonline.com/doi/full/10.1586/14737140.6.7.1111
Desai KGH. Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer. J Biomed Mater Res Part B Appl Biomater [Internet]. 2018 [citado 2022 Feb 24];106(3):1383–413. Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33943
Chen H-M, Yu C-H, Tsai T, Hsu Y-C, Kuo R-C, Chiang C-P. Topical 5-aminolevulinic acid-mediated photodynamic therapy for oral verrucous hyperplasia, oral leukoplakia and oral erythroleukoplakia. Photodiagnosis Photodyn Ther [Internet]. 2007 [citado 2022 Feb 26];4(1):44–52. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1572100006001517
Cooper JP, Reynolds CP, Cho H, Kang MH. Clinical development of fenretinide as an antineoplastic drug: Pharmacology perspectives. Exp Biol Med [Internet]. 2017 [citado 2022 Feb 23]; 242(11):1178–84. Disponible en: http://journals.sagepub.com/doi/10.1177/1535370217706952
Sauder DN. Immunomodulatory and pharmacologic properties of imiquimod. J Am Acad Dermatol [Internet]. 2000 [citado 2022 Mar 1];43(1):S6–11. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0190962200178181
Toche P Paola, Salinas L Jessica, Guzmán M M. Antonieta, Afani S Alejandro, Jadue A Nicole. Úlceras orales recurrentes: Características clínicas y diagnóstico diferencial. Rev. chil. infectol. [Internet]. 2007 [citado 2022 Mar 01];24(3):215-219. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182007000300007&lng=es
Altenburg A, El-Haj N, Micheli C, Puttkammer M, Abdel-Naser M, Zouboulis CC. The Treatment of Chronic Recurrent Oral Aphthous Ulcers. Dtsch Arztebl Int [Internet]. 2014 [citado 2022 Mar 01];111(40):665–73. Disponible en: https://www.aerzteblatt.de/10.3238/arztebl.2014.0665
Landróguez Salinas S, Flores López AR, Delgado Pérez E, García Pantoja J, Merina Díaz R, Pérez Román MD. Alternativas de uso y Eficacia Analgésica en el Dolor de Origen Dental en un Servicio de Urgencias de Atención Primaria. Int J Odontostomatol [Internet]. 2016 [citado 2022 Mar 01];10(2):221–8. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2016000200006&lng=en&nrm=iso&tlng=en
Fuentes F, Curiqueo P, Rivera C, Roa I. Anestesia Local Odontológica y su Influencia en Anomalías del Desarrollo Dental: Revisión Sistemática de la Literatura. Int J Odontostomatol [Internet]. 2015 [citado 2022 Mar 01];9(2):185–90. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2015000200002&lng=en&nrm=iso&tlng=en
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