Glycosylated hemoglobin and its correlation with both vitamin D and cortisol

Authors

Keywords:

Blood sugar (glucose), Glycosylated hemoglobin, Cortisol, Vitamin D.

Abstract

This study was conducted to evaluate the relationship and correlation between the levels of glycosylated hemoglobin, vitamin D, and cortisol. The sample was composed of 40 patients (20 male and 20 female), and the control group was composed of 40 healthy persons (20 male and 20 female). The markers measured in this study were fasting blood sugar (FBS), glycosylated hemoglobin (HbA1C), vitamin D (Vit D), and cortisol (Cort).

Our results show a significant increase (P<0.05) in the levels of FBS and Cort, and HbA1C, and a significant decrease (P<0.05) in the levels of serum Vit D in patients as compared with healthy persons. Also, this study shows a positive correlation of HbA1C with both FBS and Cort and a negative correlation with Vit D.

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References

Khalaf SJ, Aljader GH, Sarhat ER, Thuraia RS. (2021). Antidiabetic effect of Aqueous Extract of Medicago Sativa with Enhanced Histopathology of Pancreas in Alloxan Induced Diabetic Rats. P J M H S. 15(2): 492 -496.

Azzawi et al. (2022). Effect of Pumpkin Seed Oil on Histopathology of Pancreas and Some Biochemical Parameters of Streptozotocin-Induced Diabetic Rabbits.Teikyo medical Journal. 45( 07).

Wadee SA, Entedar RS, Najim RS. (2018).Effect of Moringa oleifera Extract on Serum Glucose and Interleukin-1, Interleukin-2 and Tumor Necrosis Factor α in Streptozotocin-Induced Diabetic Rats. Tikrit Medical Journal. 24;(1) :61 - 68.

Sarhat ER, Rmaid ZJ, Jabir TH (2020). Changes of salivary interleukine- 17, Apelin, Omentin and Vaspin levels in normal subjects and diabetic patients with chronic periodontitis, Ann Trop Med & Pub Health; 23:S404. DOI: http://doi.org/10.36295/ASRO.2020.23118

Entedhar RS, Wadi SA, Sedeeq BI, and Jasim NA. (2019). Study of histopathological and biochemical effect of Punica granatum L. extract on streptozotocin-induced diabetes in rabbits. Iraqi Journal of Veterinary Sciences. (33(1):189-194

Kamba A, Daimon M, Murakami H, Otaka H, Matsuki K, Sato E, et al. (2016). Association between higher serum cortisol levels and decreased insulin secretion in a general population. PLoS ONE.11(11):1-10.

Rajagopal L, Ganesan V, Abdullah SM, Arunachalam S, Kathamuthu K, and Ramraj B. (2018). Exploring the interrelationship between electrolytes, anemia, and glycosylated hemoglobin (HBA1C) levels in type 2 diabetics. Asian J Pharm Clin Res.11(1): 251-256.

Kumar Jha N. (2017). Study of lipid profile & electrolyte levels in diabetes. International Journal of Medical and Health Research. 3(9): 146-148.

Munasinghe L, Mastroeni M, Mastroeni S, et al. (2017) The Association of Serum 25-Hydroxyvitamin D Concentrations and Elevated Glycated Hemoglobin Values: A Longitudinal Study of Non-Diabetic Participants of a Preventive Health Program. Nutrients. 9: 1-11.

Angellotti E, and Pittas A G. (2017). The Role of Vitamin D in the Prevention of Type 2 Diabetes: To D or Not to D?. Endocrinology.158(7):2013-2021.

Kutlucan L, and Kutlucan A. (2016). The Effects of Initial Cortisol Levels and Vitamin D on Mortality and Hospital Infection Development in Geriatric Patients at Intensive Care Unit. Acta Medica Anatolia, 4(3):93-97.

Yaribeygi H, Panahi Y, Sahraei H, Johnston TP, Sahebkar A. (2017). The impact of stress on body function: A review. EXCLI J. 16:1057-1072.

Pittas AG, Lau J, Hu FB, Dawson-Hughes B. (2007). The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 92(6):2017-2029.

Saleh SS, Sarhat ER, Ali NH (2020) Determination of some Biochemical Marker in Postmenopausal Women with Chronic Periodontitis. Prensa Med Argent.106(6) 281.

Lee DY, Kim E, Choi MH. (2015). Technical and clinical aspects of cortisol as a biochemical marker of chronic stress. BMB Rep. 48(4):209-16.

Hamdi AQ, Sarhat ER, Ali NH. (2021). Evaluation of Lipocalin-2 and Visfatin, and Vitamin (D, C, and E) in Serum of Diabetic Patients with Chronic Periodontitis. Indian Journal of Forensic Medicine & Toxicology. 15(2), 1668–1674.

Kassaian, S.E., Goodarzynejad, H., Boroumand, M.A. et al. Glycosylated hemoglobin (HbA1c) levels and clinical outcomes in diabetic patients following coronary artery stenting. Cardiovasc Diabetol 11, 82 (2012). https://doi.org/10.1186/1475-2840-11-82

Zbaar SA, Sarhat ER, Khalaf SJ.(2022). Association of C-Reactive Protein with Risk of Complications of diabetic nephropathy. DOI: 10.21608/ EJCHEM. 2021.99 957.4868

Ocak AG, Citirik M, Gulpamuk B (2016) Relationship of Serum HbA1c and Fasting Serum Lipids with Central Macular Thickness in Patients with Type 2 Diabetes Mellitus. J Clin Res Ophthalmol 3(1): 023-026. 10.17352/2455-1414.000031

Ramadan, R. and Abdullah, A (2020). Assessment of Serum Electrolyte Levels & HbA1C Levels among Type 2 Diabetic Sudanese Patients with Macrovascular Complications in Khartoum State. Open Access Library Journal, 7, 1-9. doi: 10.4236/oalib.1106110.

Mohan, Akshay et al.(2021).“Serum cortisol is a biomolecular biomarker for severity of diabetic retinopathy.” Molecular vision vol. 27 429-437.

Saleh S, Rifaat S. (2019). Effects of Ethanolic Moringa Oleifera Extract on Melatonin, Liver and Kidney Function Tests in Alloxan- Induced Diabetic Rats. Indian Journal of Forensic Medicine & Toxicology. 13(4); 1015- 1019.

Zhang X, Deng X, Zhou J, Qiu K, Deng M, Lin Z, Mosha SS, Li W. (2020). The Association of Serum Cortisol Level with Microalbuminuria in Patients with Type 2 Diabetes And Prediabetes. Int J Med Sci; 17(18):2998-3004. doi:10.7150/ijms.48742. Available from https://www.medsci.org/v17p2998.htm

Yuling Xing, Tiantian Cheng, Fei Zhou, Huijuan Ma. (2022). The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy .15:269-280.

Khudayar M, Nadeem A, Lodi M N, et al. (2022). The Association Between Deficiency of Vitamin D and Diabetes Mellitus Type 2 (DMT2). Cureus 14(2): e22221. doi:10.7759/cureus.22221

Mahmood AR, Abdulla MS. (2015). Effect of Glibenclamide and Tomato lycopene extract on some biochemical parameters in serum of alloxan Induced diabetic rabbits. Kirkuk University Journal /Scientific Studies (KUJSS). 10(3):140- 154.

Garcia-Bailo B, El-Sohemy A, Haddad PS, et al. (2011). Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: modulation of inflammation and oxidative stress. Biologics: Targets & Therapy.5: 7–19.

Chiodini I, Adda G, Scillitani A, and Morelli V. (2007). Cortisol Secretion in Patients with Type 2 Diabetes: Relationship with Chronic Complications. Diabetes Care. 30(6):49-54.

Mohanad S. (2016). Evaluation of some vitamins related with glycemic index in type 2 diabetes patients. International Journal of Advanced Research.4(5):116-124.

Manal A, et al. (2018). Assessment of gender-related differences in vitamin D levels and cardiovascular risk factors in Saudi patients with type 2 diabetes mellitus. Saudi Journal of Biological Sciences. 25: 31-36.

Aya K, et al. (2016). Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population. PLoS One, 11(11)

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Published

2023-04-08

How to Cite

Khalaf, S. J. ., Zbaar, S. A. ., Abid, I. M. ., Sarhat, E. R. ., Hamad, M. S. ., & Sakran Abass, K. . (2023). Glycosylated hemoglobin and its correlation with both vitamin D and cortisol. AVFT – Archivos Venezolanos De Farmacología Y Terapéutica, 41(4). Retrieved from http://saber.ucv.ve/ojs/index.php/rev_aavft/article/view/25983