Commercial hormone replacement therapy jeopardized pro-inflammatory factors in experimental rat models
Keywords:
estrogen, progesterone, contraceptive, hormone replacement, interleukin, C-reactive protein.Abstract
Hormone replacement therapy is considered the easiest and most convenient contraceptive method. Commercially available contraceptive combination differs in their composition and concentration of combined constituents. These variations make some of these products preferred over others by consumers based on their side effects profile. The objective of the current research was to ascertain the pro-inflammatory influences of commercially available products. To do so, five groups of rats (ten rats each group) were exposed to Microgynon, Depo-Provera, Marvelon, and Yasmin compared to the control non-treated group. We measured pro-inflammatory markers including d-dimer, TNF-α (tumour necrosis factor-alpha), IL(interleukin)-6, IL(interleukin)-1B, and CRP (c-reactive protein). The results confirmed that Yasmin has induced the most deleterious effects on pro-inflammatory markers indicated by significant elevation of IL1B. In conclusion, hormone replacement therapy should be critically indicated and precaution raised inpatient with subclinical diseases, especially cardiovascular ones.
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