Tumor mesenquimal variante no fosfatúrica: a propósito de un caso
Abstract
Osteomalacia-inducing tumors (OIT) are usually benign, small and slow growing. OIT have an abnormal production of fibroblast growth factor 23 (FGF-23) which causes the inhibition of phosphate reabsorption in the proximal convoluted tubule and the inactivation of 1α-hydroxylase with consequent hypophosphatemia, phosphaturia and alteration of vitamin D metabolism, leading to the appearance of acquired osteomalacia. Recently a non-phosphaturic variant has been described. This clinical case presents a patient with a non-phosphaturic mesenchymal tumor, whose diagnosis was complicated by nonspecific initial symptoms.
Keywords: mesenchymal tumor, phosphaturia, osteomalacia, FGF-23, diagnosis
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Li Y, Li Y, Hui M, Liu Y, Liu X, Jin J, et al. Comparison of surgical treatments of tumor-induced osteomalacia in different locations in the lower limbs: A retrospective study. Medicine (Baltimore). 2019 Mar 1;98(11):e14846.
Folpe AL, Fanburg-Smith JC, Billings SD, Bisceglia M, Bertoni F, Cho JY. Most Osteomalacia-associated Mesenchymal Tumors Are a. Am J Surg Pathol. 2004;28(1):1–30.
Chong, William, Molinolo, Alfredo, Chen, Clara, Collins M. Tumor-induced osteomalacia. Endocr Relat Cancer. 2011;18:R53–R77.
Zinan Yin, Juan Du, Fan Yu WX. Tumor-induced osteomalacia. Osteoporos Sarcopenia [Internet]. 2018;4(4):119–27. Available from: https://doi.org/10.1016/j.afos.2018.12.001
Halperin F, Anderson RJ, Mulder JE. Tumor-induced osteomalacia: The importance of measuring serum phosphorus levels. Nat Clin Pract Endocrinol Metab. 2007 Oct;3(10):721–5.
Bahrami A, Weiss SW, Montgomery E, Horvai AE, Jin L, Inwards CY, et al. RT-PCR Analysis for FGF23 Using Paraffin Sections in the Diagnosis of Phosphaturic Mesenchymal Tumors With and Without Known Tumor Induced Osteomalacia. Am J Surg Pathol. 2009;33(9):1348–54.
Feng J, Jiang Y, Wang O, Li M, Xing X, Huo L, et al. The diagnostic dilemma of tumor induced osteomalacia: a retrospective analysis of 144 cases. Endocr J. 2017 Apr 25;64(7):675–83.
Florenzano P, Gafni RI, Collins MT. Tumor-induced osteomalacia. Bone Reports. 2017 Jan 1;7:90–7.
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