Genetic study of ITGA2 polymorphisms and impact on diabetic retinopathy risk in Al-Anbar population
Abstract
This study aimed to explore an accurate estimate of the association between ITGA2 gene polymorphisms and diabetic retinopathy risk in the population of Al-Anbar province.
Methods: The study was designed as a case-control study which included 75 persons, who were divided into two groups 25 were healthy control, while 50 were patients with Type II diabetes mellitus, and the later patients were subdivided into two groups, 25 with diabetic retinopathy and 25 without diabetic retinopathy. Blood samples were collected in Al–Nahrain Eye Specialty Center in Al-Ramadi city, west of Iraq, for the period from the seventh of September to the twenty-fifth of December 2019.
Results: The wild genotype CC/GG and mutant homozygous TT/AA genotype for C807T/G873A SNPs appeared in equal number in controls with the presence of TT/AA genotype in half of the control and most of the patients. While the heterozygous CT/GA genotype was present in approximately in the same proportion in controls and patients. There was a high relationship between C807T and G873A SNPs with the progression of diabetic retinopathy disease with X2(15.83 and 13.722) and a significant P value (<0.003 and <0.008) for both SNPs, respectively. Both SNPs were in a high linked disequilibrium with D’ (0.99), D value (0.15) at significant P<0.0001.
Conclusion: Mutant homozygous pattern for both 807TT/873AA SNPs, appears as a risk factor for diabetic retinopathy development in Al-Anbar population with co-dominant models as a genetic model for both SNPs behavior to transmit the disease.
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