Blockade of cAMP/PKA-signaling in mesenchymal progenitor cells as a promising approach to wound healing

Authors

  • Gleb N. Zyuz'kov Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia
  • Larisa A. Miroshnichenko Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia
  • Tatyana Yu. Polyakova Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia
  • Elena V. Simanina Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia

Keywords:

cAMP/PKA-signaling, progenitors, skin wound, targeted therapy, regenerative medicine

Abstract

The wound healing properties of the cAMP/PKA-signaling blocker was investigated. On the model of the skin wound the pronounced wound healing effects of the PKA inhibitor have been revealed. Implementation of the identified effects was associated with activation of mesenchymal progenitors (MPC) functions in granulation tissue. The development of this phenomenon is associated with direct exposure of the pharmacological agent to MPC in the conditions of their influence of growth factors (in particular, the growth factor of fibroblasts (FGF) secreted by stromal cells in situ. In this case, there is an increase not only in the proliferation of activity but also in the intensity of the specialization processes of progenitors. In a medium without cytokines, the cAMP/PKA-signaling blocker causes the progression of the cell signal but does not affect the rate of maturation of precursors. 

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How to Cite

Zyuz’kov, G. N., Miroshnichenko, L. A., Polyakova, T. Y., & Simanina, E. V. (2021). Blockade of cAMP/PKA-signaling in mesenchymal progenitor cells as a promising approach to wound healing. AVFT – Archivos Venezolanos De Farmacología Y Terapéutica, 40(1). Retrieved from http://saber.ucv.ve/ojs/index.php/rev_aavft/article/view/22342

Issue

Vol. 40 No. 1 (2021): AVFT-Archivos Venezolanos de Farmacología y Terapéutica

Section

Artículos