Effect of stimulation of α2-Adrenoceptor on the isolated rat heart after limitation of motor activity

Abstract

The study of the effect of limiting motor activity on the body and organ systems is an urgent task. The importance of this issue is due to not only the modern lifestyle but also the high prevalence of hypokinesia in medical practice (prolonged bed rest due to fractures, diseases of the cardiovascular system, and other diseases). The functional role of α-adrenergic receptors in adapting the cardiovascular system to changes in the motor regime requires further study. The study of the mechanisms of hypokinetic disorders, the development of methods, and means of prevention and correction of their consequences are of great social importance. Based on the foregoing, the question of the functional significance of α₂-adrenergic receptors in the heart with a change in the motor regime remains relevant. This experiment was carried out on outbred white rats growing under conditions of limited physical activity for 30 days. A Langendorff prepararion study of the effect of a α₂-adrenergic receptor agonist on the functional parameters of the isolated heart of rats (LVP, HR, CF) was carried out. To stimulate α₂-adrenergic receptors, a pharmacological agent, clonidine hydrochloride, was used at concentrations from М to М. Stimulation of α₂-adrenergic receptors led to an increase in the contraction force of the isolated heart, except for the concentration М, which had the opposite effect. Application of clonidine, in hypokinesized rats developed bradycardia and a decrease in the coronary blood flow of the isolated heart