Simulation of a cardiac cell. Part II: Applications

Rossany Roche; Rosalba Lamanna; Marisol Delgado; François Rocaries; Yskandar Hamam; Françoise Pecker

Autores

Rossany Roche Universidad Simón Bolívar, Departamento de Procesos y Sistemas
Rosalba Lamanna Universidad Simón Bolívar, Departamento de Procesos y Sistemas
Marisol Delgado Universidad Simón Bolívar, Departamento de Procesos y Sistemas
François Rocaries Groupe ESIEE, Laboratoire Algorithmique et Architecture des Systèmes Informatiques (A2SI), Cité Descartes, BP 99 93162, Noisy-Le-Grand, Paris, France.
Yskandar Hamam Groupe ESIEE, Laboratoire Algorithmique et Architecture des Systèmes Informatiques (A2SI), Cité Descartes, BP 99 93162, Noisy-Le-Grand, Paris, France
Françoise Pecker Institut National de la Santé et de la Recherche Médicale (INSERM), U581, Créteil, F-94010 France

Palavras-chave:

Cardiac simulation, Cardiac cell, E-C coupling, Calcium dynamics, Cellular simulation

Resumo

A simulator of the cardiac cell (E-C coupling process) is developed in this work, which solves the electro-chemical model of the cell proposed by Roche et al. (2004). It also contains other mathematical models as well, namely, those by Tang & Othmer (1994) and Fox et al. (2001), for comparison purposes. The simulator allows the modification of the model parameters in correspondence with the different cellular elements, to emulate cells of different species or cells under different conditions. The paper also contains an application of the simulator for testing the sensitivity of the E-C process to drugs and inhibitors, showing its intended use as a research tool in experiment design and cardiac pathology treatment.